Fabrication of heparinized nano ZnO/poly(vinylalcohol)/carboxymethyl cellulose bionanocomposite hydrogels using artificial neural network for wound dressing application

다국어 초록 (Multilingual Abstract)

This study aimed to optimize hydrogel wound dressings to achieve favorable properties of the watervapor transmission rate (WVTR) and proper degree of swelling ratio (DSR) to overcome the issues oftenassociated with most commercial dressings including improper breathability and insufficient exudateabsorption. Artificial neural network and response surface methodologies were utilized to design andmodel bionanocomposites. Besides, the effect of the ratio of components as input data, and WVTR andDSR properties as output (response) data were investigated. Hydrogel systems were produced via thefreeze–thaw method and were identified using infrared spectroscopy, dynamic light scattering, andscanning electron microscopy. To increase the antibacterial property of manufactured specimens, zincoxide nanoparticles were functionalized with heparin, and, other properties including mechanicalproperties, in vitro wound healing as well as toxicity analysis were investigated on the optimumformulation. Results showed an improvement in mechanical properties in the presence of nanoparticlesand also enhanced antibacterial property after conjugating heparin on nanoparticles. In vitro healing andcell viability results approved the biocompatibility and non-toxicity of the samples. Therefore,manufactured dressings were considered to have good DSR and WVTR, mechanical and biocompatibilityproperties and they exhibited good ability to heal and protect wounds.

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