<P>Background: The beneficial effects of endovascular therapy (EVT) in acute ischemic stroke have been demonstrated in recent clinical trials using new-generation thrombectomy devices. However, the comparative effectiveness and safety of precedi...
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https://www.riss.kr/link?id=A107473985
Park, Hong-Kyun ; Chung, Jong-Won ; Hong, Jeong-Ho ; Jang, Min Uk ; Noh, Hyun-Du ; Park, Jong-Moo ; Kang, Kyusik ; Lee, Soo Joo ; Ko, Youngchai ; Kim, Jae Guk ; Cha, Jae-Kwan ; Kim, Dae-Hyun ; Nah, Hyun-Wook ; Han, Moon-Ku ; Kim, Beom Joon ; Park, Tai Hwan ; Park, Sang-Soon ; Lee, Kyung Bok ; Lee, Jun ; Hong, Keun-Sik ; Cho, Yong-Jin ; Lee, Byung-Chul ; Yu, Kyung-Ho ; Oh, Mi-Sun ; Cho, Ki-Hyun ; Kim, Joon-Tae ; Kim, Dong-Eog ; Ryu, Wi-Sun ; Choi, Jay Chol ; Kim, Wook-Joo ; Shin, Dong-Ick ; Yeo, Min-Ju ; Sohn, Sung Il ; Lee, Ji Sung ; Lee, Juneyoung ; Yoon, Byung-Woo ; Bae, Hee-Joon
2017
-
SCI,SCIE,SCOPUS
학술저널
51-58(8쪽)
0
상세조회0
다운로드다국어 초록 (Multilingual Abstract)
<P>Background: The beneficial effects of endovascular therapy (EVT) in acute ischemic stroke have been demonstrated in recent clinical trials using new-generation thrombectomy devices. However, the comparative effectiveness and safety of precedi...
<P>Background: The beneficial effects of endovascular therapy (EVT) in acute ischemic stroke have been demonstrated in recent clinical trials using new-generation thrombectomy devices. However, the comparative effectiveness and safety of preceding intravenous thrombolysis (IVT) in this population has rarely been evaluated. Methods: From a prospective multicenter stroke registry database in Korea, we identified patients with acute ischemic stroke who were treated with EVT within 8 h of onset and admitted to 14 participating centers during 2008-2013. The primary outcome was a modified Rankin Scale (mRS) score at 3 months. Major secondary outcomes were successful recanalization defined as a modified Treatment in Cerebral Ischemia score of 2b-3, functional independence (mRS score 0-2), mortality at 3 months, and symptomatic hemorrhagic transformation (SHT) during hospitalization. Multivariable logistic regression analyses using generalized linear mixed models were performed to estimate the adjusted odds ratios (ORs) of preceding IVT. Results: Of the 639 patients (male, 61%; age 69 +/- 12; National Institutes of Health Stroke Scale score of 15 [11-19]) who met the eligibility criteria, 458 received preceding IVT. These patients showed lower mRS scores (adjusted common OR, 1.38 [95% CI 0.98-1.96]). Preceding IVT was associated with successful recanalization (1.96 [1.23-3.11]) and reduced 3-month mortality (0.58 [0.35-0.97]) but not with SHT (0.96 [0.48-1.93]). Conclusion: In patients treated with EVT within 8 of acute ischemic stroke onset, preceding IVT may enhance survival and successful recanalization without additional risk of SHT, and mitigate disability at 3 months. (C) 2017 S. Karger AG, Basel</P>