Antiulcerogenic Activity of Scoparone on HCl/Ethanol-induced Gastritis in Rats

다국어 초록 (Multilingual Abstract)

Protective effect of ethanol extract from Hericium erinaceus cultivated with Artemisia capillaries (HEAC) on gastric mucosal damage induced by 0.15M HCl in ethanol in rats was evaluated. HEAC showed higher potent protective effect on gastritis with effective dose 50 (ED50) value of 22.6mg/kg compared those of selbex and stillen at 46.5 and 44.2 mg/kg, respectively,the presently used medicines for treating gastritis. ichloromethane fraction showed a dose-dependent protective effect on gastritis with ED50 value of 18.1 mg/kg. The biologically active component of dichloromethane fraction derived from HEAC ethanolic extract was characterized by spectroscopic analysis as scoparone with protective rate of 93% and ED50 value of 4.2 mg/kg on gastritis.
Taken together, administration of HEAC and scoparone provided protective effect on the gastric lesion induced by ethanol-HCl and may therefore be a promising drug for treatment of gastritis and gastric ulcer.

참고문헌 (Reference)

1 Huh K, "on ethanol-induced gastrohemorrhagic lesions and gastric xanthine oxidase activity in rats" 88 : 269-273, 2003

2 Yamahara J, "Vascular dilatory action of Artemisia capillaries bud extracts and their active constituent" 26 : 129-136, 1989

3 Lee EW, "Two novel diterpenoids, erinacines H and I from the mycelia of Hericium erinaceum" 64 : 2402-2405, 2000

4 Park EJ, "The ethanol-soluble part of a hot-water extract from Artemisia iwayomogi inhibits liver fibrosis induced by carbon tetrachloride in rats" 52 : 875-881, 2000

5 Okuno I, "Studies of choleretic constituents in Artemisia capillaries THUMB" 34 : 769-775, 1988

6 Yim MH, "Soluble components of Herium erinaceum induce NK cell activation via production of interleukin-12 in mice splenocytes" 28 : 901-907, 2007

7 Okada Y, "Search for naturally occurring substances to precent the complications of diabetes. II. Inhibitory effect of coumarin and flavonoid derivatives on bovine lens aldose reductase and rabbit platelet aggregation" 43 : 1385-1387, 1995

8 Jang SI, "Scoparone inhibits PMA-induced IL-8 and MCP-1 production through suppression of NF-kappa B activation in U937 cells" 78 : 2937-2943, 2005

9 이광호, "Pathogenesis and prevention of stomach cancer" Korean Academy of Medical Sciences 11 (11): 373-385, 199610

10 Choi WS, "Inhibitory effect on proliferation of vascular smooth muscle cells and protective effect on CCl4-induced hepatic damage of HEAI extract" 100 : 176-179, 2005

11 Lee SE, "Inhibitory effect on aflatoxin B1-8, 9-epoxide formation and anti-complementary activity of methanol extract from Hericium erinaceus cultivated with Artemisia iwayomogi" 12 : 183-186, 2003

12 Vacca LL, "In Laboratory manual of histochemistry" Raven Press 1985

13 손창규, "Hericium erinaceum induces Maturation of Dendritic Cells Derived from Human Peripheral Blood Monocytes" JOHN WILEY & SONS LTD 24 : 14-19, 201001

14 Schmeda-Hirschmann G, "Gastroprotective activity of the diterpene solidagenone and its derivatives on experimentally induced gastric lesions in mice" 81 : 111-115, 2002

15 Pan SL, "Esculetin inhibits Ras-mediated cell proliferation and attenuates vascular restenosis following angioplasty in rats" 65 : 1897-1905, 2003

16 Kenmoku H, "Erinacine Q, a new erinacine from Hericium erinaceum, and its biosynthetic route to erinacine C in the basidomycete" 66 : 571-575, 2002

17 Won-Sik Choi, "Curative Effects of Extracts of Hericium erinaceum Hypha Cultivated with Artemisia capillaris (HEAC) and Their Primary Active Compounds on Rat Liver Disease" 한국응용생명화학회 54 (54): 531-537, 2011

18 Razdan TK, "Chromenes and coumarins from Skimmia laureola" 26 : 2063-2069, 1987

19 Xu H, "Chemical analysis of Hericium erinaceum polysaccharides and effect of the polysaccharides on derma antioxidant enzymes, MMP-1 and TIMP-1 activities" 47 : 33-36, 2010

20 Lee EB, "Araloside A, an antiulcer constituent from the root bark of Aralia elata" 28 : 523-526, 2005