Oligodendrocytes (OLs) continue to be generated from OL precursors (OPs) in the adult mammalian brain. Adult‐born OLs are believed to contribute to neural plasticity, learning and memory through a process of “adaptive myelination,” but how adult...
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https://www.riss.kr/link?id=O108134444
2021년
-
1932-8451
1932-846X
SCOPUS;SCIE
학술저널
975-984 [※수록면이 p5 이하이면, Review, Columns, Editor's Note, Abstract 등일 경우가 있습니다.]
0
상세조회0
다운로드다국어 초록 (Multilingual Abstract)
Oligodendrocytes (OLs) continue to be generated from OL precursors (OPs) in the adult mammalian brain. Adult‐born OLs are believed to contribute to neural plasticity, learning and memory through a process of “adaptive myelination,” but how adult...
Oligodendrocytes (OLs) continue to be generated from OL precursors (OPs) in the adult mammalian brain. Adult‐born OLs are believed to contribute to neural plasticity, learning and memory through a process of “adaptive myelination,” but how adult OL generation and adaptive myelination are regulated remains unclear. Here, we report that the glia‐specific G protein‐coupled receptor 37‐like 1 (GPR37L1) is expressed in subsets of OPs and newly formed immature OLs in adult mouse brain. We found that OP proliferation and differentiation are inhibited in the corpus callosum of adult Gpr37l1 knockout mice, leading to a reduction in the number of adult‐born OLs. Our data raise the possibility that GPR37L1 is mechanistically involved in adult OL generation and adaptive myelination, and suggest that GPR37L1 might be a useful functional marker of OPs that are committed to OL differentiation.
Mechanisms of oligodendrocyte progenitor developmental migration
Neuronal development in the cochlea of a nonhuman primate model, the common marmoset