Reaction Medium as the Installing Reservoir for Key Functionalities in the Molecules

다국어 초록 (Multilingual Abstract)

The solvent is an important entity in a chemical reaction, generally, required for the effective collision of the reactant molecules. By looking at the chemical nature, physic‐chemical properties, and more importantly, smart selection, reaction solvents attract synthetic chemists for their effective use as reagents in a chemical reaction. For the installation of small key functionalities in the molecules, reaction solvents provide attractive, atom‐economical, greener, and also less costly alternatives to other reagent‐based strategies. For instance, particular reaction solvents can serve as a multipurpose building block for various units, such as O, −CO, S, C, N, −SOMe, −NMe2, −CONMe2, −Me, −CHO, −CN, etc. The use of a reaction solvent as a reagent can be highly beneficial for some complex design in case of some contradictory reagents, waste management and byproduct minimization. The present review article highlights the recent progress in solvent use as a multipurpose precursor and will be helpful for the development of effective synthetic methodologies and their utility in the design of complex molecules, particularly for late‐stage modifications in drug discovery programs.
I found my purpose! This Minireview highlights the recent progress using a solvent as a multipurpose precursor for the installation of key functional groups in molecules. The use of a solvent as a reagent can be highly beneficial for the complex design of some intriguing reagents, waste management, and byproduct minimization.