갑상선 기능 저하증 환자에서의 혈중 Insulin과 C-peptide의 변화 = Serum Insulin and C-Peptide Levels in Patients with Hypothyroidism

다국어 초록 (Multilingual Abstract)

Background : Studies for the effect of thyroid hormones on secretion of insulin and glucose metabolism have been reported, but those results appear to be controversial. Methods : We have investignated the levels of serum C-peptide and insulin following the oral glucose load in 19 patients with hypothyroidism and 14 normal subjects. Results : 1) T도 mean fating level of serum C-peptide in hypothyroidism was somewhat elevated. The response of serum C-peptide was significantly enhanced 2 hours after oral glucose tolerance test in hypothyroid patients (5.16±2.31 Vs 2.01±1.05 ng/ml) (p<0.05). 2) Serum insulin response was exaggerated after oral glucose tolerance test in hypothyroidism. (GTT 1 hour : 90.74±33.56 Vs 61.19±22.91uU/ml, GTT 2 hour : 74.23±36.47 Vs 49.30±0.83 uU/ml) (p<0.05). 3) Blood glucose response has been significantly augmented in hypothyroid patients after oral glucose tolerance test. (GTT 1 hour : 129.47±40.20 Vs 98.21±9.10mg/dl) (p<0.05). 4) The ratio of C-peptide to insulin had no significant difference between patients with hypothyroidism and normal subjects statistically. Conclusion : These results suggested that the slowing of C-peptide and insulin degradation due to hypometabolism in hypothyroidism could be contributed to higher serum levels of the C-peptide and insulin.