비알코올성 건강검진 수진자에서 혈청 Gamma-glutamyl transferase의 대사증후군과 연관성 = The Relationship between Gamma-Glutamyltransferase and Metabolic Syndrome in the Non Alcoholic Health Screen Examinees

다국어 초록 (Multilingual Abstract)

Background : Gamma-glutamyltransferase (rGTP) is one of the biliary enzymes, and is synthesized in epithelial cells of the intrahepatic bile duct. Increased rGTP is conventionally interpreted as a marker of alcohol abuse and/or liver damage. Recently, and association between rGTP and metabolic syndrome such as diabetes, obesity, hyperlipidemia, and hypertension has been reported. The aim of this study was to assess the association between rGTP activity and parameters of metabolic syndrome in the non-alcoholic health screen examinees.
Methods : A total of 4,110 health screen examinees (2,051 men, 2,059 women) who participated in health screening at the health promotion center in Kosin Medical Center from March, 1997 to December, 2003 were enrolled in this study. All participants have no evidence of viral hepatitis and alcohol abuse. The clinical, biochemical and metabolic parameters analyzed by multiple regression and logistic methods.
Results : Almost of all variables (age, weight, blood pressure, body mass index (BMI), waist circumference (WC), total cholesterol, triglyceride, fasting blood glucose and rGTP) except high density lipoprotein (HDL) cholesterol were significantly high in men than women (p<0.05). When subjects were grouped according to the rGTP level, group 1 (0~<20 U/L) and group 2 (20 U/L<~<40 U/L) and group 3 (>40 U/L), significant differences were noticed in almost of all variables (weight, blood pressure, BMI, WC, total cholesterol, triglyceride, fasting blood glucose) among each group (p<0.01). The age adjusted odds ratio between WC and abnormal rGTP level was 1.760 in men and 2.475 in women (p<0.01). As subjects were grouped according to their number of components in metabolic syndrome, the numbers of subjects with abnormal rGTP concentration were increased according to the numbers of components in metabolic syndrome (p<0.05). There was a significant positive correlation among waist circumference (r=0.192, p<0.01), waist and hip ratio (r=0.293, p<0.01), systolic blood pressure (r=0.115, p<0.01), total cholesterol (r=0.135, p>0.01), triglyceride (r=o.228, p<0.01) and rGTP.
Conclusion : These results suggested that increased rGTP level in non alcoholic health examinees is closely associated with metabolic syndrome. Elavated rGTP may not always indicate increased alcohol consumption, but may simply suggest the existence of the metabolic syndrome.