HCC : PE-068 ; A relationship between HCV RNA viral load and clinical outcome in patients with hepatocellular carcinoma = HCC : PE-068 ; A relationship between HCV RNA viral load and clinical outcome in patients with hepatocellular carcinoma

다국어 초록 (Multilingual Abstract)

Background/Aim: The HCV RNA viral load is the predictive factor for sustained viral response in the treatment of chronic hepatitis C. However, it has been reported that HCV RNA viral load is not predictive of eventual outcome of chronic hepatitis C. The relation between HCV RNA viral load and clinical outcome of hepatocellular carcinoma (HCC) is not elucidated, yet. We investigated the relation of HCV RNA viral load to the clinical outcome in HCC. Methods: Among 453 HCC patients, 34 consecutive patients diagnosed with chronic hepatitis C virus infection were classified into two groups by HCV RNA viral load. Group I (n=19) was defined as low HCV RNA viral load less than 2x106 copies/ml, and Group II (n=15) defined as high HCV RNA viral load over 2x106 copies/ml. Characteristics of HCC, complications of cirrhosis, and overall survival were compared between the two groups. Results: Sixteen patients were male (47.1%) and the median age was 69 years. There was no significant difference in age, gender, Child-Pugh score, MELD score, tumor stage, portal vein invasion, distant metastasis, α-fetoprotein, and histology between the two groups. For complications of cirrhosis includeing variceal hemorrhage, ascites, hepatorenal syndrome and hepatic encephalopathy during follow up, there was no significant difference between both groups. Median overall survival was 48.7 months (95% CI, 30.9-66.6) for group I and 54.0 months (95% CI, 36.1-71.9) for group II. (p=0.859). Conclusion: HCV RNA viral load did not affect the clinical outcome in patients with hepatocellular carcinoma.