人系大腸菌의 抗菌性物質耐性 및 R因子의 分布 = Antimicrobial Resistance and R Factors in Esherichia coli Isolated from Human Stools

국문 초록 (Abstract)

抗菌劑를 投與받은 患者群과 받지않은 醫師 또는 學生群의 大便中 大腸菌의 藥劑耐性을 檢査하였던바 患者群의 菌에는 chloramphenicol, tetracycline, streptomycin, sulfisomidine 및 ampicillin(AP)에 對한 耐性菌株는 全分離菌의 60%以上이였으나 醫師群과 學生群에는 30%以下였으며 醫師群과 學生群사이에는 別差異가 없었다.
이들 耐性菌은 4劑以上에 多藥劑耐性인 것이 大部分이었고 感受性菌은 醫師群 및 學生群에서는 約70%以上이었으나 患者群에서는 22.4%였으며 耐性菌 保有者도 患者群에 越等히 많았다.
耐性菌의 耐性傳達率은 藥劑에 따라서 多少의 差異는 있었으나 患者群과 他群사이에 別로 큰 差異가 없었고 大體로 多藥劑耐性균의 耐性傳達率이 높았다. 傳達되는 耐性의 pattern을 보면 그 菌의 耐性全部를 傳達하는 것이 많았으나 一部만을 傳達하는 것도 있었고 AP耐性이 特히 잘 傳達되는 것을 보았다.

다국어 초록 (Multilingual Abstract)

In order to know the distribution of drug-resistant and R factor-bearing Escherichia coli in humans, the organisms isolated from stools of inpatients who received various antimicrobial treatment, doctors, and students were subjected for the study. About 60% of strains isolated from patients were resistant to chloramphenicol, tetracycline, streptomycin, sulfisomidine and ampiciliin(AP), but the strains resistant to these drugs were less than 30% among E. coil isolated from doctors and students, without marked difference between doctors and students. Most of the resistant strains were multiply resistant to 4 or more drugs. The strains susceptible to all test drugs were 22.4% amnng patient isolates and appaoximately 70% among isolates from doctors and students. The persons carrying resistant strains were more frequently encountered among patients than doctors and students. About 60% of resistantt strains transferred their resistance to E. coli ML 1410. The rate of transfer differed by the drugs used but not by the origins of strains. Some strains transferred their complete resistance patterns to the recipients, and some others transferred no or partial resistance to the recipient. AP resistance was most frequently transferred than other drugs used.