정신분열증 환자에서 시각유발전위 P100의 지표학적 뇌영상 = Topographic Brain Mapping of Visual Evoked Potential P100 in Schizophrenia

다국어 초록 (Multilingual Abstract)

PI00 is one of the most stable and consistent visual evoked potentials. This is closely linked
with visual information processing which has been thought to be generated in the cortical
area (calcarine area). It has been extensively evaluated in psychiatric reseach, and many investigators
have been trying to seek the relation between visual information processing and psychopathology,
and it’ s clinical significance.
It is now possible to map the spatiotemporal evaluation and statistical results of VEP PI00
wave form using the topographic brain mapping system developed by computer graphics and
electronic engineering.
Recently, the topographic brain m apping of VEP PI00 has been applied to evaluate the
disturbance of visual information process, particularly with regard to the topographic distribution
of P100 in schizophrenics. However, the results have been inconsistent
With these aspects in mind, this study was designed to evaluate not only the amplitude
but also the topographic distribution of VEP P100 in schizophrenics, and to examine the
availability of the characteristic findings of VEP PI00 mapping as one of the biological markers.
The subjects were consisted of 40 Schizophrenics who had been admitted to Our Lady
of Mercy Hospital and Catholic University Medical College from September, 1989 to A ugust
1992. They did not take any psychotrophic medications for more than 4 weeks. 42 normal
controls also did not take any psychotrophic medications for more than 4 weeks.
The results were as follows :
1) In schizophrenics the latency of V EP P100 was 102msec. Positive and negative m ax im um
amplitudes of P100 was 4.65士 3.44|iV in O 2 and ᅳ 2.4 8士 2.02|iV in F 3, respectively. The amplitude
of P100 showed negativity in frontal area and positivity in occiptial area, and showed symmetrical
topographic distribution.
2) In normal controls, the latency of V E P P100 was 104msec. Positive and negative m ax im um
amplitudes of P100 was 3.95± 2.42|iV in O 2 , and ᅳ 2.55± 2.03|iV in F 3 , repectively. The amplitude
of P100 showed negativity in frontal area and positivity in occipital area showed symmetrical
topographic distibution.
3) At th latency point VEP PI00 showed no differences of amplitude in entire cortex, and
showed no differences of topographic distribution between the groups.
4) Spatiotemporal analysis of VEP PI00 showed similiar beginning and ending point in
time, and showed simliar topographic distribution during entire PI00 process in both groups.
In light of our findings, it seems likely that the visual information processing shown in
schzophrenics’ optic pathway, visual cortex and other association area is not different from
that shown in normal control

목차 (Table of Contents)

• 서 론
• 대상 및 방법
• 결 과
• 고 찰
• 결 론
• References