Pathological and immunohistochemical changes on psoriasis: comparison between biologics and oral medication treatment = Pathological and immunohistochemical changes on psoriasis: comparison between biologics and oral medication treatment

다국어 초록 (Multilingual Abstract)

Background: Psoriasis is a chronic inflammatory skin disorder primarily affecting the epidermis. Patients with moderate-to-severe psoriasis have been treated with oral medications including methotrexate and cyclosporine. Nowadays, targeted monoclonal antibodies showed evident effect on psoriasis, but little is known about pathological and immunohistochemical alterations in psoriasis treated with biologics.
Objectives: We compared the pathologic and immunohistochemical changes between patients with psoriasis, treated with biologics and oral medications.
Methods: Skin samples from 10 patients with psoriasis treated with biologics and 10 patients with psoriasis treated with oral medication were obtained before and after treatment. We analyzed histological and immunohistochemical changes of skin samples after treatment.
Results: The histological changes between baseline and after treatment showed that most of classic histological features of psoriasis such as parakeratosis or regular acanthosis were almost cleared in both groups, particularly in biologics group. The results of qualitative and quantitative analysis of immunohistochemical stains showed significant reduction of cytokines, especially for IL-23, IL-36r, and IL-10 cytokines in biologics group.
Conclusion: In psoriasis, biologics could improve pathological and immunohistological features in psoriasis in addition to improvement of severity and symptoms of psoriasis than oral medication.