Duodenal Adenocarcinoma of Brunner Gland Origin: A Case Report

다국어 초록 (Multilingual Abstract)

We report a case of adenocarcinoma originating from the duodenal Brunner glands in a 47-yearold female patient. The lesion was 0.8 cm in extent and located at the posterior wall of the first part of the duodenum. Histologically, the tumor showed transition from non-neoplastic Brunner glands through dysplastic epithelium into adenocarcinoma. The carcinoma cells were strongly positive for MUC6 protein, which is an epithelial marker for the Brunner glands. Tumor protein p53 was overexpressed in the carcinoma cells, but not in the non-neoplastic or dysplastic epithelium. Dystrophic calcification was predominant. This is the first case report of duodenal adenocarcinoma of Brunner gland origin in Korea.

참고문헌 (Reference)

1 Kitagori K, "Image of the month: adenocarcinoma derived from Brunner's gland" 8 : A26-, 2010

2 Fenoglio-Preiser CM, "Gastrointestinal pathology: an atlas and text" Lippincott Williams & Wilkins 471-, 2008

3 Ohta Y, "Early primary duodenal carcinoma arising from Brunner's glands synchronously occurring with sigmoid colon carcinoma: report of a case" 38 : 756-760, 2008

4 Kim K, "Clinicopathologic characteristics and mucin expression in Brunner's gland proliferating lesions" 58 : 194-201, 2013

5 Koizumi M, "Carcinoma arising from Brunner's gland in the duodenum after 17 years of observation: a case report and literature review" 1 : 103-109, 2007

6 Chang HK, "Adenocarcinoma of the small intestine: a multi-institutional study of 197 surgically resected cases" 41 : 1087-1096, 2010

7 Iwamuro M, "Adenocarcinoma in situ arising from Brunner's gland treated by endoscopic mucosal resection" 2017 : 2017

8 Kamei K, "A case of adenocarcinoma of the duodenum arising from Brunner's gland" 7 : 433-437, 2013