저산소 스트레스에 노출된 생쥐의 면역기능 변동에서 IL-4의 역활 = Role of IL-4 in the Changes of Immune Function in Mice Exposed to Hypoxic Stress

다국어 초록 (Multilingual Abstract)

This study was aimed to investigate the role of IL-4 in the alterations of immune function in mice after chronic, repeated exposure of different levels of hypoxic stress. Four experimental groups were studied: one for home cage control (NH), others for environmental control (20%) and hypoxia-exposed groups (15% or 10%). Different levels of normoxic or hypoxic environment (20%, 15%, or 10% of oxygen will balanced nitrogen, respectively) were subjected to adult male BALB/c mice daily for an hour, 5 days per week, over 10 weeks. At the end of hypoxic exposure period, sera of the mice were taken and their IL-4 levels were measured by a sandwich ELISA method. The changes of body weight of the animals showed significantly lower increase in the 10% group, suggesting that the repeated hypoxic exposure worked as a stressful environment to them. The IL-4 levels, however, showed no differences among the experimental groups. These results indicate that IL-4 may not play a significant role in the mediation of stress effects to immunologic outcomes in this stress paradigm, and that studies about the role of Th1-type cytokines may be necessary fur further investigation.

목차 (Table of Contents)

• Ⅰ.서론
• Ⅱ.연구내용 및 방법
• 1.연구내용
• 2.연구방법
• 3.자료 분석
• Ⅲ.결과
• 1.저산소 노출기간 중 생쥐의 체중 변화
• 2.저산소 노출 후 생쥐 혈청 내 IL-4 농도
• Ⅳ.고찰
• Ⅴ.요약 및 결론