Immunostimulatory Effect of Fermented Red Ginseng in the Mouse Model

다국어 초록 (Multilingual Abstract)

In this study, Woongjin fermented red ginseng extract (WFRG) was evaluated for its potential ability to act as an adjuvant for the immune response of mice. For the in vitro study, macrophages were treated with serial concentrations (1 ㎍/mL, 10 ㎍/mL, and 100 ㎍/mL) of WFRG. For in vivo studies, mice were administered different concentrations (10 ㎎/㎏/day, 100 ㎎/㎏/day, and 200 ㎎/㎏/day) of WFRG orally for 21 days. In vitro, the production of nitric oxide and TNF-α by RAW 264.7 cells increased in a dose-dependent manner. In vivo, WFRG enhanced the proliferation of splenocytes induced by two mitogens (i.e., concanavalin A and lipopolysaccharide [LPS]) and increased LPS-induced production of TNF-α and IL-6, but not IL-1β. In conclusion, WFRG has the potential to modulate immune function and should be further investigated as an immunostimulatory agent.

목차 (Table of Contents)

• ABSTRACT
• INTRODUCTION
• MATERIALS AND METHODS
• RESULTS
• DISCUSSION
• REFERENCES