Poster Session : PS 0895 ; Lower GI Tract : Assessment of Mucosal Infl ammation in Right Colonic Diverticular Disease = Poster Session : PS 0895 ; Lower GI Tract : Assessment of Mucosal Infl ammation in Right Colonic Diverticular Disease

다국어 초록 (Multilingual Abstract)

Background: Recent studies suggest that the diverticular disease (DD) could be considered as a chronic inflammatory bowel disease. It was never investigated about the presence of inflammatory infiltrate in right colonic diverticular disease, and the grading of inflammatory infiltrate according to disease severity. The aim of this study was to assess and grade the mucosal inflammatory infiltrate in different degrees of DD and to compare them with healthy controls. Methods: Thirty consecutive patients with endoscopic diagnosis of DD (10 with asymptomatic diverticulosis, 10 with symptomatic uncomplicated DD, and 10 with acute uncomplicated diverticulitis) and 10 healthy controls were enrolled. They underwent colonoscopy, and 2~4 biopsy samples of colonic mucosa were collected in the right colon. In DD, biopsies were taken in the peridiverticular area. The presence of inflammatory infiltrate was assessed by a semi-quantitative lymphocytes and neutrophils count. Immunohistochemical staining was performed using anti-CD3 monoclonal antibodies for lymphocytes, and anti-CD15 monoclonal antibodies for neutrophils. Results: The mean lymphocytic cell density was significantly increased according to the degree of DD (P=0.000) (Table 1). There was higher lymphocytic cell density even in asymptomatic diverticulosis than healthy controls. A neutrophilic inflammatory in- filtrate was found only in acute uncomplicated diverticulitis. Conclusions: Microscopic inflammatory infiltration was increased according to the degree of right-sided DD. There was higher inflammatory cell density even in asymptomatic diverticulosis than healthy controls, which implies that right-sided diverticulosis may be considered as chronic inflammatory disease.