규칙적인 트레드밀 운동이 추위 스트레스에 의한 흰쥐의 불안장애에 미치는 영향 = The effect of regular treadmill exercise on cold stress-induced anxiety disorder in mice

다국어 초록 (Multilingual Abstract)

In the present study, the effect of regular treadmill exercise on cold stress-induced anxiety disorder in mice was investigated. ICR mice were divided into four groups: the control-rest group, the control-exercise group, the cold-rest group, and the cold-exercise group(n=5 in each group). Cold stress to the mice was induced by exposure mice into the cold room(4 ℃) for 3 h six times a week during 3 weeks. Treadmill exercise load consisted of running at a speed of 5 m/min for 30 min once a day for 3 weeks. Elevated plus maze test was performed to determine anxiety disorder. Our results revealed that regular treadmill exercise suppressed cold stress-induced anxiety disorder in mice. The findings of our study provide evidence that regular treadmill exercise may ameliorate cold stress-induced anxiety disorder.

목차 (Table of Contents)

• Abstract
• Ⅰ. 서론
• Ⅱ. 연구방법
• Ⅲ. 결과
• Ⅳ. 논의
• Ⅴ. 결론
• 참고 문헌

참고문헌 (Reference)

1 McNaughton, N., "The pituitary-adrenal axis and the different behavioral effects of buspirone and chlordiazepoxide" 54 (54): 51-56, 1996

2 Pratt, J. A., "The neuroanatomical basis of anxiety" 55 (55): 149-181, 1992

3 Hata, T., "The abnormal open- field behavior of SART-stressed rats and effects of some drugs on it" 48 (48): 479-490, 1988

4 Kita, T., "Stress state caused by alteration of rhythms in environmental temperature, and the functional changes in mice and rats. Nippon Yakurigaku Zasshi" 71 (71): 195-210, 1975

5 Steenbergen, H. L., "Sex-dependent effects of inescapable shock administration on shuttlebox-escape performance and elevated plus-maze behavior" 48 (48): 571-576, 1990

6 Britton, K. T., "Pregnane steroid alphaxalone attenuates anxiogenic behavioral effects of corticotropin releasing factor and stress" 41 (41): 399-403, 1992

7 Hata, T., "Platelet hypoaggregability in rats exposed to SART stress (repeated cold stress)" 65 (65): 617-629, 1992

8 McBlane, J. W., "Effects of two stressors on behaviour in the elevated X-maze: Preliminary investigation of their interaction with 8-OH-DPAT" 116 (116): 173-182, 1994

9 Hata, T., "Depressive state with anxiety in repeated cold-stressed mice in forced swimming tests" 79 (79): 243-249, 1999

10 Uchida, S., "Decrease in muscarinic acetylcholine receptors in the small intestine of mice subjected to repeated cold stress" 22 (22): 2197-2203, 1978

11 Heinrichs, S. C., "Corticotropin-releasing factor antagonist reduces emotionality in socially defeated rats via direct neurotropic action" 581 (581): 190-197, 1992

12 Zangrossi, H. Jr, "Behavioral consequences in animal tests of anxiety and exploration of exposure to cat odor" 29 (29): 381-388, 1992

13 Hata, T., "Behavioral characteristics of SART-stressed mice in the forced swim test and drug action" 51 (51): 849-853, 1995

14 Rodgers, R. J., "Anxiety enhancement in the murine elevated plus maze by immediate prior exposure to social stressors" 53 (53): 383-388, 1993

15 Hata, T., "A characteristic pattern of active avoidance behavior in SART-stressed rats" 49 (49): 436-440, 1989