Engineering considerations of iPSC-based personalized medicine

다국어 초록 (Multilingual Abstract)

Personalized medicine aims to provide tailored medical treatment that considers the clinical, genetic, and environ‑ mental characteristics of patients. iPSCs have attracted considerable attention in the feld of personalized medicine; however, the inherent limitations of iPSCs prevent their widespread use in clinical applications. That is, it would be important to develop notable engineering strategies to overcome the current limitations of iPSCs. Such engineering approaches could lead to signifcant advances in iPSC-based personalized therapy by ofering innovative solutions to existing challenges, from iPSC preparation to clinical applications. In this review, we summarize how engineering strategies have been used to advance iPSC-based personalized medicine by categorizing the development process into three distinctive steps: 1) the production of therapeutic iPSCs; 2) engineering of therapeutic iPSCs; and 3) clinical applications of engineered iPSCs. Specifcally, we focus on engineering strategies and their implications for each step in the development of iPSC-based personalized medicine.