Kaposi`s sarcoma (KS) is a locally aggressive endothelial tumor belonging to the family of vascular sarcoma. Four variants have been described: classic KS, endemic African KS, KS associated with immunosuppressive therapy, and AIDS-related KS. Up to re...
Kaposi`s sarcoma (KS) is a locally aggressive endothelial tumor belonging to the family of vascular sarcoma. Four variants have been described: classic KS, endemic African KS, KS associated with immunosuppressive therapy, and AIDS-related KS. Up to recently, there are some controversies whether KS is a reactive proliferative disorder or a true malignant neoplasm and spontaneous remission of KS has been rarely reported. In previous literatures, spontaneous remission of KS has been reported in immune compromised patients. However, spontaneous remission of classic KS is uncommon. Herein, we report a case of classic KS which showed spontaneous remission, suggesting that KS may be a reactive disorder. A 77-year-old man presented with multiple purpuric nodules on the trunk and extremities for 3 months. No mucosal involvement was noted. Except for the history of angina pectoris and hypertension, he had no remarkable history such as immunosuppression. Laboratory findings including anti-HIV antibody were also unremarkable. Histopathological examination revealed slit like vascular spaces infiltrating the entire dermis and the vascular spaces were lined by spindle endothelial cells. With positive results of HHV-8 stain, the diagnosis of classic KS was made. However, at the 3-month follow-up while in the process of staging work-up, all skin lesions were spontaneously regressed without any specific treatment.