한국인 양극성 정동장애 환자에서 Apolipopretein E 유전자의 다형성 = Genetic Polumorphism of Apolipoprotein E in Korean Bipolar Disorder Patients

다국어 초록 (Multilingual Abstract)

Objectives: Although genotype of apolipoprotein E has been investigated in many neuropsychiatric disorders, results were controversial and even contradictory. The purpose of this study was to investigate the nature of apolipoprotein E in bipolar disorder, and compare it with healthy control group in terms of distribution of apolipoprotein E genotype and allele. Methods: Using polymerase chain reaction and amplified refractory mutation system, apolipoprotein E genotype were identified in 115 bipolar disorder patients and 115 healthy control persons. Results: The results were as follows: 1) When genotype of apolipoprotein E were classified as E2/2, E2/3, E2/4, E3/3, E3/4, E4/4, according to phenotypes, there were no statistical differences in genotyprs between two groups. 2) In terms of allele frequency, there were also no statistical differences between two groups. Conclusion: These results suggest that genotypes and alleles of apolipoprotein E seem to unrelatrd to pathogenesis of bipolar disorder.