자궁경부암의 방사선치료 후 방사선대장염 발생의 위험인자 = Risk Factors of Radiation Colitis Following Radiotherapy of Uterine Cervix Carcinoma

다국어 초록 (Multilingual Abstract)

Background/Aims: Radiation therapy is an effective treatment modality for uterine cervix carcinoma. The adverse effects, however, can be seen as acute and chronic colitis, which may lead to serious complications including fistula, bleeding, and stricture. The aim of this study was to evaluate the clinical characteristics of radiation- induced colitis and analyze the predictive factors of chronic bowel complications. Methods: All 192 consecutive patients were enrolled from January 1995 to April 1998. The characteristics of acute and chronic complications were analyzed retrospectively. The acute and chronic complications were graded according to EORTC/RTOG grading criteria. Risk factors of chronic colitis were obtained by univariate and multivariate analyses. Results: Of 192 patients, 142 (74%) developed acute bowel complications (38/grade I, 93/II, and 11/III). The common symptoms were diarrhea, abdominal pain, and nausea. Fifty-six (29%) of the 192 patients developed chronic bowel complications (23/grade I, 10/II, 11/III, and 12/IV). In univariate analysis, age, body mass index, hypertension, abdominal surgery, and intracavitary radiation (ICR) were statistically significant in the development of chronic colitis. Multivariate analysis revealed that ICR had the greatest prognostic significance. Conclusions: The patients treated with ICR have a high probability of developing chronic radiation-induced colitis. A meticulous follow-up is needed to manage these patients promptly. ( Korean J Gastroenterol 2002; 40: 247-254)