Biomarkers for Evaluating the Inflammation Status in Patients with Cancer

다국어 초록 (Multilingual Abstract)

Inflammation can be a causative factor for carcinogenesis or can result from a consequenceof cancer progression. Moreover, cancer therapeutic interventions can also induce aninflammatory response. Various inflammatory parameters are used to assess the inflammatorystatus during cancer treatment. It is important to select the most optimal biomarker amongthese parameters. Additionally, suitable biomarkers must be examined if there are noknown parameters. We briefly reviewed the published literature for the use of inflammatoryparameters in the treatment of patients with cancer. Most studies on inflammation evaluatedthe correlation between host characteristics, effect of interventions, and clinical outcomes.
Additionally, the levels of C-reactive protein, albumin, lymphocytes, and platelets were themost commonly used laboratory parameters, either independently or in combination withother laboratory parameters and clinical characteristics. Furthermore, the immune parametersare classically examined using flow cytometry, immunohistochemical staining, and enzymelinkedimmunosorbent assay techniques. However, gene expression profiling can aid inassessing the overall peri-interventional immune status. The checklists of guidelines, such asSTAndards for Reporting of Diagnostic accuracy and REporting recommendations for tumorMARKer prognostic studies should be considered when designing studies to investigate theinflammatory parameters. Finally, the data should be interpreted after adjusting for clinicallyimportant variables, such as age and cancer stage.

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