급성 및 만성 염증에서 생약복합제 GCSB-5의 항염증 작용에 관한 연구 = Anti-Inflammatory Activities of a Herbal Preparation GCSB-5 on Acute and Chronic Inflammation

다국어 초록 (Multilingual Abstract)

− GCSB-5 is a purified extract from a mixture of 6 Oriental herbs (Ledebouriellae Radix, Achyranthis Radix, Acanthopanacis Cortex, Cibotii Rhizoma, Glycine Semen, and Eucommiae Cortex) that have been widely used for the treatment of inflammatory diseases in the East Asia. The aim of this study was to investigate the anti-inflammatory potential of GCSB-5. The animals used in this study were administered either vehicle or GCSB-5 (30, 100, 300, and 600 mg/kg) orally. The GCSB- 5 significantly inhibited the increase of acetic acid-induced vascular permeability (30.9-34.2% inhibition at 30-300 mg/kg). The swelling of the rat’s hind paw induced by carrageenan was significantly inhibited by GCSB-5 in doses of 100, 300, and 600 mg/kg. Maximal inhibition (50.9%) was obtained with GCSB-5 at dose of 300 mg/kg. However, it did not have any anti-inflammatory action in the rheumatoid arthritis induced by Freund’s complete adjuvant or in the granuloma induced by carrageenan.
Our finding suggest that GCSB-5 has a anti-inflammatory activity.

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