Morphine이 Norepinephrine 代謝에 미치는 影響 : Ⅰ. Morphine이 家兎의 腦, 心臟 및 腎臟의 norepinephrine 含量과 轉換에 미치는 效果 Ⅰ. The effect of morphine on the content and turnover of norepinephrine in the brain, heart and kidney of rabbits = The Effect of Morphine on the Metabolism of Norepinephrine

다국어 초록 (Multilingual Abstract)

Numerous studies using a variety of species implicated brain catecholamin in the analgesic activity of morphine. Yet the ability of single doses of morphine to change brain norepinephrine level would appear to be a species dependent phenomenon.
This study was performed to observe the effect of morphine on the content and turnover of norepinephrine(NE) in the brain, heart and kidney of rabbits.
The results were obtained as follows ;
1. Various doses (5, 10 and 20㎎/㎏) of morphine increased the brain NE and renal NE content and decreased the cardiac NE content 20 minutes after the morphine injection, and these NE changing effects of morphine were dose-dependent.
2. The time courses (20, 60 and 90 min.) of the effect of morphine (10 and 20㎎/㎏) on the NE content in several organs of rabbits showed an initial increase in the brain NE content, acute decrease in the cardiac NE content and gradual increase in the renal NE content.
3. The initial increase of brain NE content induced by morphine was continuously increased by iproniazid pretreatment, but the decreased cardiac NE and increased renal NE content induced by morphine were inhibited by the pretreatment.