KIF1B polymorphisms associated with the risk of inflammatory demyelinating disease in Korean population

다국어 초록 (Multilingual Abstract)

In the present study, we explored the possibleassociation between KIF1B polymorphisms and inflammatorydemyelinating disease (IDD) susceptibility. Elevensingle nucleotide polymorphisms (SNPs) were selected forthe present study based on the literature, as well as linkagedisequilibrium, minor allele frequency, and location. TheSNPs were genotyped in 178 IDD subjects consisting of 99neuromyelitis optica subjects, 79 multiple sclerosis subjects,and 237 healthy controls (Total N = 415). We nextpreformed logistic analysis to validate associationsbetween the KIF1B polymorphisms and the risk of IDD.
Statistical analyses revealed that rs17396382 and ht4 weresignificantly associated with IDD susceptibility with oddsratios of 2.22 and 2.17 (P = 0.001 and 0.004; Pcorr = 0.01and 0.03, respectively). In addition, although P values forsix variants (rs3748576, rs7520935, rs2275424,rs11576866, rs17411502, and rs11121552) and one haplotype(ht1) did not reach the threshold of significance aftercorrection for multiple testing, the SNPs showed a nominalassociation in primary analysis (P = 0.02 * 0.04). Ourresults suggest that rs17396382 and ht4 might be involvedin IDD pathogenesis.

참고문헌 (Reference)

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