폐경 후 요로계 변화와 폐경호르몬치료 효과 = Changes of Urinary Tract after Menopause and Effectiveness of Menopausal Hormone Replacement Therapy

국문 초록 (Abstract)

폐경 후 여성호르몬 감소에 따른 요로기능의 변화로 과민성 방광, 복압성 요실금, 재발성 요로감염과 같은 질환의 발생률이 높아지게 된다. 본 연구는 여성호르몬이 하부요로기능에 미치는 영향 및 폐경 후 요로기능의 변화와 함께 여러형태의 폐경호르몬요법에 따른 과민성 방광, 복압성 요실금, 재발성의 치료 또는 예방효과에 대해서 보고자 한다.

다국어 초록 (Multilingual Abstract)

Because sex hormones influence the lower urinary tract, menopause can cause several urinary diseases including overactive bladder, stress urinary incontinence and recurrent urinary tract infection. However, the results of many clinical studies have indicated that menopausal hormone replacement therapy is not effective for the treatment of previous diseases, especially via the oral route. Although estrogen vaginal cream or pessary is an effective treatment for overactive bladders and can prevent recurrent urinary tract infection, its beneficial effects only last for the duration of the treatment. If patients with previous mentioned urologic disease have other local symptoms and conditions, such as atrophic vaginitis and dyspareunia, local estrogen replacement therapy will be helpful in relieving the local symptoms. However, the potential for breast cancer or return of withdrawal of bleeding, patient`s age, adverse effect of systemic administration, estrogen-progesterone combination therapy, and effectiveness among other treatment modalities must be considered before a treatment decision can be made. In this article, we will review the current issues on the relationship among urinary tract and sex hormone and menopause, and the effectiveness of menopausal hormone replacement therapy for the treatment of overactive bladders, stress urinary tract incontinence and recurrent urinary tract infection. (J Korean Soc Menopause 2011;17:136-141)

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