Design, formulation and evaluation of Azithromycin binary solid dispersions using Kolliphor series for the solubility and in vitro dissolution rate enhancement

다국어 초록 (Multilingual Abstract)

The main purpose of this investigation isincreasing of the solubility and dissolution rate of Azithromycinby solid dispersion technique using KolliphorP 237, Kolliphor P 338 and Kolliphor P 407. Kolliphor(P 237, P 338 and P 407) in various properties by weight{(1:0.5), (1:1), (1:1.5) and (1:2)}, utilizing solvent evaporationmethod. Dissolution studies carried out in phosphatebuffer with pH 6.0 according to US pharmacopoeiamethod. The drug release profiles were studied, so wefound that the dissolution rate of the drug (by calculatingthe dissolution parameters) was significantly increasecompared to pure drug, also solubility of physical mixturesas well as solid dispersions increased compared to theintact drug. For example solubility of the drug increasedfrom 85–753 lg mL-1 (for Kolliphor P 237; 8 timesmore). The best results were as follows: KolliphorP 237[Kolliphor P 338[Kolliphor P 407. IR spectrarevealed no chemical incompatibility between drug andpolymer. Drug-polymer interactions were investigatedusing differential scanning calorimetry, powder X-raydiffraction and scanning election microscopy. The dissolutionrate and solubility of Azithromycin solid dispersionswas improved significantly using Kolliphor. Inaddition, the simplicity of this method is very effective andhave been met the project objectives.

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