온담탕합총명탕(溫膽湯合聰明湯) 열수추출물과 초미세분말이 cytokine과 건망증 생쥐모델 기억력감퇴에 미치는 영향 = The Effects of Ondam-tanghapChongmyung-tang(Wendantanghecongmingtang) Hot Water Extract & Ultra-fine Powder on Proinflammatory Cytokine of Microglia and Memory Deficit Model온담탕합총명탕(溫膽湯合聰明湯) 열수추출물과 초미세분말이 cytokine과 건망증 생쥐모델 기억력감퇴에 미치는 영향

다국어 초록 (Multilingual Abstract)

Objectives: This experiment was designed to investigate the effect of the ODTCMT hot water extract & ultra-fine Powder on Alzheimer`s Disease Model Induced by βA. Methods: The effects of the ODTCMT hot water extract on expression of IL-1β, IL-6, TNF-α in BV2 microglial cell line treated by lipopolysacchaide(LPS) were investigated. The effects of the ODTCMT hot water extract & ultra-fine powder on the behavior of the memory deficit mice induced by scopolamine were investigated. Results: 1. The ODTCMT hot water extract significantly suppressed the production of TNF-α, IL-6 and IL-1β in BV2 microglial cell line treated with LPS. 2. The ODTCMT hot water extract & ultra-fine powder groups showed significantly inhibitory effect on the scopolamine-induced impairment of memory in the experiment of Morris water maze. Conclusions: These results suggest that the ODTCMT hot water extract & ultra-fine powder may be effective for the prevention and treatment of Alzheimer`s disease. Investigation into the clinical use of the ODTCMT hot water extract & ultra-fine powder for Alzheimer`s disease is suggested for future research.