HCC : PO-11 ; Portal vein thrombosis is the most important factor for the survival after the tumor resection = HCC : PO-11 ; Portal vein thrombosis is the most important factor for the survival after the tumor resection

다국어 초록 (Multilingual Abstract)

Background: The prognostic factors related to long-term survival after surgical resection of HCC are still undetermined. The aim of study was to determine long-time survival and its prognostic factors among the HCC patients who had received surgical resection. Methods: This is the retrospective study. The patients received surgical resection in our hospital from Jun 1999 to Oct 2011. In total 60 pts who were diagnosed as HCC and treated with both TACE and subsequent tumor resection (n=25) or surgical resection only (n=35). We analyzed their survival outcomes according to their clinical, radiological and pathological parameter. We tried to find out which factors affect the longterm survival. Results: The patients were aged 58.1±10.1 years. During the follow-up period, 26 pts (43%) died and the overall median survival 57 months. The 1-, 3-, and 5-year survival rates were 82.6%, 55.8% and 40.6%, respectively. The demographic and laboratory data were as follows: male(83%), HBsAg positivity (70%), cirrhosis (75%), AFP 17.0 (1.7-105,740) ng/mL, pre-op TACE (42%), single tumor (78%), right lobe tumor (77%), tumor size 3.7 (0.7-15.6)cm, PVT(20%). Univariate analysis showed that gender, differentiation, portal vein thrombosis (PVT), UICC stage and HBsAg positivity affect the long-term survival. But, PVT is the only significant factor with multivariate analysis (p=0.02), Exp (B) 5.6 (1.3-25). Conclusions: The long-term survival rate was very high in HCC patients with surgical resection. The selection bias in relation to reserve function, early UICC stage, and referral hospital should be considered to interpret the rate. Vascular invasion is the only significant prognostic factor for postoperative survival.