새로운 정신안정제 Ro 5-3350의 임상 사용경험 = Clinical Trial of A New Benzodiazepine Derivative Ro 5-3350

다국어 초록 (Multilingual Abstract)

Ro 5-3350 is a benzodiazepine derivative, which has shown muscle relaxant, sedative and anti-convulsant effects in animal experiments. This study was done to investigate its suitability for use in anesthesiology.
The patients were selected at random and divided into three groups. The first. group was given 10 mgs of the drug intramuscularly one hour prior the proposed. surgery. The second group was given additional 10 mgs of the-drug intramuscularly on the evening before the operation. The third group was given diazepamnn and treated similarly, i. e., 10 mgs of diazepam was given intramuscularly twice as the second group.
The pre-operative psychic sates, the circulatory, respiratory and muscle relaxation during the surgery and the post-operative recovery status was analyzed statistically by applying the x' test.
The conclusions can be summarized as follows:
1) The patients could sleep soundly with Ro 5-3350 on the night preceding the. surgery but there was no statistical difference between Ro 5-3350 and diazepam with equivalent doses in sleep inducing action.
2) *Sedative effect of single injection of the drug was equivalent with double injection of diazepam. Sedative effect was enhanced with the doubt doses of Ro 5-3350.
3) During the surgery, respiration and circulation was not affected by the drug. The difference between Ro 5-3350 and diazepam in potentiating muscle relaxation, during the surgery was not significant.
4) The difference between the drug and diazepam group in post-operative-recovery was highly- significant. Ro 5--3350 sedated the patients better and -exerted analgesic effect significantly. Vomiting and appetite was aggreviated with diazepam, especially after penthrane anesthesia compared with halothane -anesthesia. Ante- and retrograde amnesia was observed in several cases.
5) Application to anesthesia for cardioversion was found improper, because the -drug caused prolonged sleep and air-way obstruction due to muscle relaxation after the procedure.
6) Hiccough and hallucination was observed in small number of the cases.
For pre-medication, single dose of Ro 5-3350 prior to the surgery was recommended and additional dose given at the night before surgery was poorly tolerated by the patients. Post-operative use to alleviate pain was found to be effective.