광조건이 Codyceps militaris의 Cordycepin 생산에 미치는 영향 = Effect of Light Conditions on Production of Cordycepin of Cordyceps militaris

다국어 초록 (Multilingual Abstract)

The effect of light on production of cordycepin (3'-deoxyadenosine) was investigated using Cordyceps militaris. Among Cordyceps spp. tested, C. militaris KCTC 6064 was the best for cordycepin production, After 120-hr cultivation of C. militaris KCTC 6064 at $24^{\circ}C$ in YMG broth with light (1,000 lux), 51.6 mg/l of cordycepin was produced. In general, production of cordycepin with light illumination was better than that without light. Cordycepin production under light illumination was enhanced up 96-hr cultivation, whereas after 96-hr, cordycepin production was decreased.

국문 초록 (Abstract)

Cordyceps militaris의 액체배양시 cordycepin(3'-deoxyadenosine) 생산성에 영향을 주는 광조건의 영향을 조사하였다. 사용된 Cordyceps 속균중에서 C. militaris KCTC 6064가 우수한 cordycepin 생산성을 보여주었다. 광조건(1,000 lux)에서 YM배지에 C.militaris KCTC 6064을 120시간 배양한 결과, 51.6 mg/l의 가장 우수한 cordycepin 생산성을 보여주었다. 광조건에서의 cordycepin 생산성은 96시간 배양까지는 증가되었으나, 96시간 이후에는 cordycepin 생산이 감소하였다.

참고문헌 (Reference)

1 "selective growth inhibitor derived from liquid culture of Cordyceps militarlis against Clostridium spp" 2744-2748, 2000

2 "The effect of cordycepin on malaria parasites" 514-520, 1971

3 "Messenger and heterogeneous nuclear RNA in HeLa cells differential inhibition by cordycepin Further evidence on the structure of cordycepin" 480-482, 19701878-18851966

4 "Isolation of 3'-deoxyadenosine from the liquid medium of Cordyceps militaris" kle (kle): 1965189-193

5 "Investigationon artificial fruiting of Cordyceps militaris" 6-10, 2002

6 "Incorporation of cordycepin into ribonucleic acid of human tumor cells" 646-653, 1965

7 "Icons of medical fungi form China" Science press 60-85, 1987

8 "Cordycepin analogues of 2'5'-oligoadenylate inhibit human immunodeficiency virus infection via inhibition of reverse transcriptase" 2027-2033, 1991

9 "Cordycepin a metabolic product form cultures of Cordyceps militaris" 2299-2300, 1951

10 "Antifungal activity of 3'-deoxyadenosine" 1424-1427, 1998