Alzheimer``s disease (AD) is a representative neurodegeneration disorder that is increasing rapidly with the prolonging life expectancy and increasing elderly population· The two major pathological hallmarks of AD are the β-amyloid (Aβ) protein and...
Alzheimer``s disease (AD) is a representative neurodegeneration disorder that is increasing rapidly with the prolonging life expectancy and increasing elderly population· The two major pathological hallmarks of AD are the β-amyloid (Aβ) protein and neurofibrillary tangles (NFTs) in the brain and leading to neuronal cell death and ultimately cognitive dysfunction· Also brain insulin resistance and mitochondria dysfunction may significantly contribute to the AD, indicating that inhibiting and reducing of Aβ protein and NFTs is the main targets for prevention and treatment of AD· Recently, exercise decrease the Aβ protein, NFT and neuronal cell death and increase the neurogenesis and ultimately enhancement of cognitive function in AD· Moreover, exercise increase the insulin signaling pathway- relatived protein and mitochondria biogenesis factor, indicating that exercise may be beneficial in prevention or treatment of AD· However, in AD, the most of therapies have depended primarily drugs until now and effects of exercise is very short research· Therefore, more research is necessary to prove effect of exercise on AD·