자궁내 인공수정 시술을 받은 고령 난임여성과 비고령 난임여성에서의 임신성공 확률 및 영향 요인의 비교: 2016년 보조생식술 국가지원사업기준 = Comparison of Clinical Pregnancy Rates and Affecting Factors Between Elderly and Young Infertile Females After Intra-Uterine Insemination: Benefited by ‘National Medical-aid Program for ART (assisted reproductive technology) in 2016

다국어 초록 (Multilingual Abstract)

Purpose: : The purpose of this study was to evaluate the intrauterine insemination (IUI) success rate and to define the variables for predicting success. Methods: The secondary data analysis was used with data collected from infertile females who underwent IUI in Fertility and IVF (In Vitro Fertilization) clinics, who benefited from the ‘National Medical-aid Program for ART (assisted reproductive technology) in 2016’, in which the data of 34,920 IUI cases were retrospectively reviewed. The primary outcome measure was the clinical pregnancy rate in elderly and young infertile females. Data were analyzed by descriptive statistics, χ2 test and logistic regression. Results: The pregnancy rate was 12.1% (2,095 cases) in elderly infertile females and 15.6% in young infertile females (2,758 cases) (χ2=87.90, p<.001). Using the logistic regression analysis, clinical pregnancy was positively associated with the ovulatory factor (OR=1.48, p<.001) and male factor (OR=1.19, p<.05) in elderly infertile females. It was positively associated with the ovulatory factor (OR=1.30, p=.001) and the peritoneal cavity factor (OR=0.58, p<.05) in young infertile females. Conclusion: Our results indicate that the pregnancy rate in young infertile females was higher than that in old infertile females, and the IUI is the effective option in pregnancies in all ages with infertility due to the ovulatory factor. Additionally, further studies are necessary to fully describe pregnancy experiences for all the infertile females.

목차 (Table of Contents)

• 서 론 연구 결과 논 의 결 론

참고문헌 (Reference)

1 이우석, "정상 배란 주기의 불임 여성에서 clomiphene citrate 단독 사용과 GnRH antagonist 병합 요법의 임상적 효용성에 관한 연구" 대한생식의학회 33 (33): 1-17, 2006

2 서혜정, "임부의 스트레스, 우울 및 배우자와 가족의 지지가 모성 정체성에 미치는 영향" 한국여성건강간호학회 26 (26): 84-92, 2020

3 김윤정, "산부인과 전문병원 내원환자의 난임 특성과 보조생식술 유형이 임신에 미치는 영향" 한국산학기술학회 17 (17): 318-326, 2016

4 손영수, "불임 환자의 치료에서 Mild Ovarian Hyperstimulation을 이용한Single IUI와 Double IUI의 비교" 대한생식의학회 31 (31): 191-200, 2004

5 이혜신, "보조생식술을 받는 여성의 불확실성과 배우자 지지가 난임 관련 삶의 질에 미치는 영향" 한국여성건강간호학회 26 (26): 72-83, 2020

6 이영선, "난임 상담 서비스 체계 구축을 위한 난임 상담 실태 및 요구도 조사" 한국모자보건학회 24 (24): 52-63, 2020

7 대한내분비학회, "고프로락틴혈증(hyperprolactinemia)의 진료지침" 대한내분비학회 25 (25): 180-182, 2010

8 Sarah Armstrong, "What is the best treatment option for infertile women aged 40 and over?" Springer Science and Business Media LLC 30 (30): 667-671, 2013

9 Yoo Shin Kim, "Treatment of Female Infertility" Korean Medical Association (KAMJE) 50 (50): 406-414, 2007

10 Lindsey B, "The psychology of infertility" 28 (28): 41-47, 2013

11 Sonia E, "The Boston IVF handbook of infertility: a practical guide for practitioners who care for infertile couples" CRC Press 85-, 2017

12 Ministry of Health and Welfare, "Support for infertility couple" Ministry of Health and Welfare

13 Yogev Y, "Pregnancy outcome at extremely advanced maternal age" 203 (203): 558.e1-558.e7, 2010

14 Lee SY, "Policy challenges for pregnancy after the age of 35 years" 7 (7): 24-35, 2014

15 Kim GC, "Infertility treatment success rates are low, costs are increasing"

16 ESHRE Capri Workshop Group, "Fertility and ageing" 11 (11): 261-276, 2005

17 Mark X. Ransom, "Does increasing frequency of intrauterine insemination improve pregnancy rates significantly during superovulation cycles?" Elsevier BV 61 (61): 303-307, 1994

18 Lee SS, "Current state challenges of policy response to low fertility and population aging" 9 (9): 51-65, 2016

19 Gilberto Ibérico, "Analysis of factors influencing pregnancy rates in homologous intrauterine insemination" Elsevier BV 81 (81): 1308-1313, 2004

20 Kim DS, "Advanced maternal age women and adverse birth outcomes in Korea" Korea Institute for Health and Social Affairs 2013

21 Lee JI, "A comparison between fallopian tube sperm perfusion(FSP)and intrauterine insemination(IUI)for the Treatment of Infertility" 43 (43): 2121-2126, 2000