P-36 Association of Specific Immunoglobulin E to Staphylococcal Enterotoxin with Airway Hyperresponsiveness in Asthma Patients = P-36 Association of Specific Immunoglobulin E to Staphylococcal Enterotoxin with Airway Hyperresponsiveness in Asthma Patients

다국어 초록 (Multilingual Abstract)

Background: Specific immunoglobulin E (IgE) sensitization to staphylococcal enterotoxin (SE) has been recently considered to be related to allergic disease, including asthma, however, association of sIgE to SE with airway hyperresponsiveness (AHR) has not been well studied. Methods: We enrolled 81 asthma patients admitted to the Severance Hospital in Korea from March 1st, 2013 to February 28th, 2015 and retrospectively reviewed the electronic medical records of the enrolled subjects. We measured the levels of sIgE to SE (A/B) in serum of all subjects using ImmunoCAP® 250 (Phadia, Uppsala, Sweden) system. We defined positive to SE-sIgE as more than 0.10 kU/mL. Results: The SE-sIgE level was not significantly correlated with asthma severity (FEV1, FEV1/FVC, sputum eosinophils, and serum eosinophils), whereas the SE-sIgE level in patients with positive AHR (mean ± Standard error of the mean, 0.606 ± 0.273 kU/mL) was significantly higher than that in patients with negative AHR (0.062 ± 0.015 kU/mL; p-value 0.034). In regression analysis, SE sensitization (sIgE to SE ≥ 0.010 kU/mL) was a significant risk factor for AHR, after adjustment for age, sex, FEV1, and sputum eosinophils (odds ratio 7.090; 95% confidence interval, 1.180-42.600; p-value 0.032). Prevalence of SE sensitization was higher in patients with allergic rhinitis and non-atopic asthma patients compared to patients without allergic rhinitis and atopic asthma patients, respectively, but without statistical significance. Conclusions: SE sensitization is significantly associated with AHR.