Stress granules dynamics: benefits in cancer

다국어 초록 (Multilingual Abstract)

Stress granules (SGs) are stress-induced subcellular compartments,which carry out a particular function to cope with stress. Thesegranules protect cells from stress-related damage and cell deaththrough dynamic sequestration of numerous ribonucleoproteins(RNPs) and signaling proteins, thereby promoting cell survivalunder both physiological and pathological condition. Duringtumorigenesis, cancer cells are repeatedly exposed to diversestress stimuli from the tumor microenvironment, and the dynamicsof SGs is often modulated due to the alteration of geneexpression patterns in cancer cells, leading to tumor progressionas well as resistance to anticancer treatment. In this mini review,we provide a brief discussion about our current understandingof the fundamental roles of SGs during physiological stress andthe effect of dysregulated SGs on cancer cell fitness and cancertherapy.

참고문헌 (Reference)

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