Chemodynamic therapy (CDT) utilizes iron‐initiated Fenton chemistry to destroy tumor cells by converting endogenous H2O2 into the highly toxic hydroxyl radical (.OH). There is a paucity of Fenton‐like metal‐based CDT agents. Intracellular glutat...
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https://www.riss.kr/link?id=O114845735
Li‐Sen Lin ; Jibin Song ; Liang Song ; Kaimei Ke ; Yijing Liu ; Zijian Zhou ; Zheyu Shen ; Juan Li ; Zhen Yang ; Wei Tang ; Gang Niu ; Huang‐Hao Yang ; Xiaoyuan Chen
2018년
-
0044-8249
1521-3757
학술저널
4996-5000 [※수록면이 p5 이하이면, Review, Columns, Editor's Note, Abstract 등일 경우가 있습니다.]
0
상세조회0
다운로드다국어 초록 (Multilingual Abstract)
Chemodynamic therapy (CDT) utilizes iron‐initiated Fenton chemistry to destroy tumor cells by converting endogenous H2O2 into the highly toxic hydroxyl radical (.OH). There is a paucity of Fenton‐like metal‐based CDT agents. Intracellular glutat...
Chemodynamic therapy (CDT) utilizes iron‐initiated Fenton chemistry to destroy tumor cells by converting endogenous H2O2 into the highly toxic hydroxyl radical (.OH). There is a paucity of Fenton‐like metal‐based CDT agents. Intracellular glutathione (GSH) with .OH scavenging ability greatly reduces CDT efficacy. A self‐reinforcing CDT nanoagent based on MnO2 is reported that has both Fenton‐like Mn2+ delivery and GSH depletion properties. In the presence of HCO3−, which is abundant in the physiological medium, Mn2+ exerts Fenton‐like activity to generate .OH from H2O2. Upon uptake of MnO2‐coated mesoporous silica nanoparticles (MS@MnO2 NPs) by cancer cells, the MnO2 shell undergoes a redox reaction with GSH to form glutathione disulfide and Mn2+, resulting in GSH depletion‐enhanced CDT. This, together with the GSH‐activated MRI contrast effect and dissociation of MnO2, allows MS@MnO2 NPs to achieve MRI‐monitored chemo–chemodynamic combination therapy.
MnO2 zeigt Fenton‐ähnliche Eigenschaften in Bezug auf Mn2+‐Freisetzung und Glutathion(GSH)‐Abbau; hieraus resultiert eine verbesserte chemodynamische Wirksamkeit bei der Krebsbehandlung. Eine aktivierbare theranostische Plattform auf Basis multifunktionaler MnO2‐beschichteter mesoporöser Siliciumoxidnanopartikel (MS@MnO2‐NPs) wurde für die MRI‐überwachte kombinierte chemotherapeutische und ‐dynamische Therapie (CDT) entwickelt. ADS=antioxidatives Abwehrsystem.
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