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다국어 초록 (Multilingual Abstract)

We report a visualization assay for carcinoembryonic antigen (CEA). The assay was prepared based on target-specific recognition, aptamer-based DNAzyme self-catalysis, and colorimetric reaction. Aptamer of CEA was gathered at the surface of magnetic beads for sandwiched co-conjugate when CEA was added. The second aptamer (Apt2) on the beads was folded into G-quadruplex by KCl to make G-quadruplex-hemin DNAzyme with hemin. Apt2-based DNAzyme catalyzed H2O2-mediated oxidation of 3,3′,5,5′-tetramethylbenzidine, resulting in color changes and significant increase in absorption intensity at 450 nm (ΔA450nm). Yellow products can be observed with naked eyes when over 1.0 ng/mL CEA was added and there was a linear correlation between ΔA450 nm and CEA concentrations in the range of 0.1–8.0 ng/mL with the detection limit of 0.06 ng/mL. The proposed method was then used to determine CEA in human serum from healthy people and tumor patients, revealing a correlation with data from the electrochemiluminescent immunoassay. Owing to its simplicity, selectivity, and low-cost, this method is a promising candidate for detecting CEA and clinical diagnosis of cancer.

참고문헌 (Reference)

1 P. Thomas, 92 : 59-, 1995

2 Y. T. Lan, 59 : 717-, 2012

3 J. Pan, 388 : 279-, 2007

4 W. Wang, 23 : 1244-, 2015

5 B. R. Clark, 121 : 257-, 1982

6 T. Yang, 239 : 76-, 2017

7 Y. Song, 211 : 297-, 2016

8 J. Yakovleva, 74 : 2994-, 2002

9 S. Qu, 766 : 94-, 2013

10 S. Zhang, 72 : 47-, 2008

1 P. Thomas, 92 : 59-, 1995

2 Y. T. Lan, 59 : 717-, 2012

3 J. Pan, 388 : 279-, 2007

4 W. Wang, 23 : 1244-, 2015

5 B. R. Clark, 121 : 257-, 1982

6 T. Yang, 239 : 76-, 2017

7 Y. Song, 211 : 297-, 2016

8 J. Yakovleva, 74 : 2994-, 2002

9 S. Qu, 766 : 94-, 2013

10 S. Zhang, 72 : 47-, 2008

11 S. Matsuzawa, 161 : 59-, 1993

12 G. Werstuck, 282 : 296-, 1998

13 T. Hermann, 287 : 820-, 2000

14 C. Zong, 86 : 9939-, 2014

15 D. Verga, 51 : 7379-, 2015

16 T. Li, 24 : 3551-, 2009

17 J. Chen, 51 : 12373-, 2015

18 J. Zhu, 49 : 5459-, 2013

19 M. Deng, 130 : 13095-, 2008

20 H. Shu, 37 : 15-, 2013

21 Y. He, 4 : 56756-, 2014

22 K. Liang, 139 : 4330-, 2014

23 Y. Xu, 84 : 62-, 2012

24 H. Zhang, 61 : 45-, 2014

25 S. Yang, 78 : 174-, 2016

26 D. Horák, 30 : 1751-, 2007

27 L. Pan, 450 : 304-, 2015

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연월일	이력구분	이력상세
2023	평가예정	해외DB학술지평가 신청대상 (해외등재 학술지 평가)
2020-01-01	평가	등재학술지 유지 (해외등재 학술지 평가)
2008-01-01	평가	SCI 등재 (기타)
2006-01-01	평가	등재학술지 유지 (등재유지)
2004-01-01	평가	등재학술지 유지 (등재유지)
2001-07-01	평가	등재학술지 선정 (등재후보2차)
1998-01-01	평가	등재후보학술지 선정 (신규평가)