Review: optically-triggered phase-transition droplets for photoacoustic imaging

다국어 초록 (Multilingual Abstract)

Optically-triggered phase-transition droplets have been introduced as a promising contrast agent for photoacoustic andultrasound imaging that not only provide significantly enhanced contrast but also have potential as photoacoustic theranosticmolecular probes incorporated with targeting molecules and therapeutics. For further understanding the dynamics ofoptical droplet vaporization process, an innovative, methodical analysis by concurrent acoustical and ultrafast opticalrecordings, comparing with a theoretical model has been employed. In addition, the repeatability of the droplet vaporization-recondensation process, which enables continuous photoacoustic imaging has been studied through the sameapproach. Further understanding the underlying physics of the optical droplet vaporization and associated dynamics mayguide the optimal design of the droplets. Some innovative approaches in preclinical studies have been recently demonstrated,including sono-photoacoustic imaging, dual-modality of photoacoustic and ultrasound imaging, and super-resolutionphotoacoustic imaging. In this review, current development of optically triggered phase-transition droplets andunderstanding on the vaporization dynamics, their applications are introduced and future directions are discussed.

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