Dopamine Loaded SiO2 Coated Fe3O4 Magnetic Nanoparticles: A New Anticancer Agent in pH‐Dependent Drug Delivery

다국어 초록 (Multilingual Abstract)

In this present study, we have shown dopamine acts as very good agent in killing cancer cells with very high rate. We have used silica coated iron oxide magnetic particles as dopamine drug delivery agent. We have synthesized iron oxide (Fe3O4) magnetic nanoparticles (MNPs), and coated it with silicon dioxide (SiO2), then loaded it with dopamine (DA) which has been used here as anticancer drug. Here a significant improvement was found in case of drug release under acidic pH than normal blood pH. The MNPs are characterized using X‐ray diffraction (XRD), Energy Dispersive Analysis of X‐rays (EDAX), Fourier transform infrared (FTIR), Field Emission Scanning Electron Microscopy (FESEM), Transmission Electron Microscopy (TEM), High Resolution Transmission Electron Microscopy (HRTEM), Selected Area Electron Diffraction (SAED) and vibrating sample magnetometer (VSM) to confirm its structural, morphological and magnetic properties. Particles after characterization were involved in investigation of DA drug release by altering pH for better treatment of cancer. The results are very important and promising.
The schematic illustration represents an efficient pH‐ sensitive drug delivery process. Here the drug carrier i.e core‐shell MNPs (Fe3O4 nanoparticles as core and mesoporous silica as shell) was loaded with dopamine drug. The acidic medium enhanced release of drug hence this will be effective for selective drug delivery as cancer cell environment is acidic.