PubMed 논문을 활용한 한약재 6종에 관한 연구 동향 분석 = Analyzing Research Trends on Six Traditional Herbal Medicines Using Papers on PubMed

다국어 초록 (Multilingual Abstract)

In Due to its long history, traditional herbal medicine has been the subject of extensive research, aiming to validate its reliability, safety, low side effects, and therapeutic efficacy. This research has sought to discover lead compounds for the development of natural medicines and explore their potential as complementary treatments in modern medicine by integrating modern biomedical methodologies. Many studies on herbal medicine have been conducted and published as research papers. In this study, we analyzed and examined the trends in research on traditional herbal medicine from various perspectives. We selected six key herbal medicines (Astragali Radix, Coptidis Rhizoma, Paeoniae Radix, Glycyrrhizae Radix et Rhizoma, Scutellariae Radix, and Angelica Gigantis Radix) and conducted a search and analysis of related papers on PubMed. In the analysis of the trends by year, research on these herbal medicines has shown a steep increase since the late 2000s, particularly during the COVID-19 pandemic period between 2020 and 2022 when research activity surged significantly. In the analysis by country, the majority of research (74.6%) was conducted in China, with most research being carried out in the East Asian region. Regarding research methods, animal experiments accounted for approximately 40% of the studies, followed by cell experiments, literature analysis, and clinical trials. Text mining was employed to map disease names identified in the abstracts to MeSH disease categories. Pathological conditions, signs and symptoms group was the most frequently studied area, indicating a focus on common symptoms or complex symptoms that are challenging to categorize under a single disease. Finally, we analyzed the relationship between the efficacy and indications of the six selected herbal medicines and their integration into contemporary scientific disease research. This analysis highlighted areas where traditional herbal medicine utilization has been integrated into research and shed light on aspects that may be overlooked in current research directions.