Recent trends in studies of biomolecular phase separation

다국어 초록 (Multilingual Abstract)

Biomolecular phase separation has recently attracted broad interest,due to its role in the spatiotemporal compartmentalizationof living cells. It governs the formation, regulation, anddissociation of biomolecular condensates, which play multipleroles in vivo, from activating specific biochemical reactions toorganizing chromatin. Interestingly, biomolecular phase separationseems to be a mainly passive process, which can be explainedby relatively simple physical principles and reproducedin vitro with a minimal set of components. This Mini reviewfocuses on our current understanding of the fundamental principlesof biomolecular phase separation and the recent progressin the research on this topic.

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