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あ ぁ か が さ ざ た だ な は ば ぱ ま や ゃ ら わ ゎ ん い ぃ き ぎ し じ ち ぢ に ひ び ぴ み り う ぅ く ぐ す ず つ づ っ ぬ ふ ぶ ぷ む ゆ ゅ る え ぇ け げ せ ぜ て で ね へ べ ぺ め れ お ぉ こ ご そ ぞ と ど の ほ ぼ ぽ も よ ょ ろ を
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á à Á À é è É È ç Ç ê
Ä Ö Ü ä ö ü ß
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      국내 중증패혈증 입원 환자에서 초기 소생술 지표의 특성

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      https://www.riss.kr/link?id=T12671833

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      다국어 초록 (Multilingual Abstract)

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      Background
      Early goal-directed therapy (EGDT) for severe sepsis, targeting central venous pressure (CVP), mean arterial pressure and central venous oxygen saturation (ScvO2), has been shown to reduce mortality in the emergency department. Our aim was to review the characteristics of such parameters for patients hospitalized with sepsis in Korea.
      Methods
      We conducted a retrospective analysis of 474 patients, all of whom became septic while assigned to a general ward of Asan Medical Center between March, 2008 and August, 2010. Collective hemodynamic and laboratory parameters were compared with those published by Rivers et al.
      Results
      A total of 360 patients with severe sepsis (n=92) and with septic shock (n=268) qualified for study and was compared side-by-side with the cohort of Rivers et al. By contrast, our subjects displayed higher mean (±SD) APACHE II scores (23.3 ±9.1 vs 20.9 ±7.2) with significantly differing indices; namely, higher ScvO2 (74.5 ±2.6% vs 48.9 ±12.3%), lower lactate concentration (3.5 ±3.0 mmol/L vs 7.3 ±4.6 mmol/L), and higher CVP (7.8 ±5.2 mmHg vs 5.7 ±8.5 mmHg), (p<0.001 for all comparisons). The 28-day mortality of our patients was 28.3%.
      Conclusion
      In patients hospitalized with severe sepsis, disparities between our investigation and the Rivers' EGDT study, in terms of ScvO2, CVP, and lactate concentration, suggest that threshold levels of ScvO2 and CVP be re-evaluated as resuscitation goals.
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      Background Early goal-directed therapy (EGDT) for severe sepsis, targeting central venous pressure (CVP), mean arterial pressure and central venous oxygen saturation (ScvO2), has been shown to reduce mortality in the emergency department. Our aim was ...

      Background
      Early goal-directed therapy (EGDT) for severe sepsis, targeting central venous pressure (CVP), mean arterial pressure and central venous oxygen saturation (ScvO2), has been shown to reduce mortality in the emergency department. Our aim was to review the characteristics of such parameters for patients hospitalized with sepsis in Korea.
      Methods
      We conducted a retrospective analysis of 474 patients, all of whom became septic while assigned to a general ward of Asan Medical Center between March, 2008 and August, 2010. Collective hemodynamic and laboratory parameters were compared with those published by Rivers et al.
      Results
      A total of 360 patients with severe sepsis (n=92) and with septic shock (n=268) qualified for study and was compared side-by-side with the cohort of Rivers et al. By contrast, our subjects displayed higher mean (±SD) APACHE II scores (23.3 ±9.1 vs 20.9 ±7.2) with significantly differing indices; namely, higher ScvO2 (74.5 ±2.6% vs 48.9 ±12.3%), lower lactate concentration (3.5 ±3.0 mmol/L vs 7.3 ±4.6 mmol/L), and higher CVP (7.8 ±5.2 mmHg vs 5.7 ±8.5 mmHg), (p<0.001 for all comparisons). The 28-day mortality of our patients was 28.3%.
      Conclusion
      In patients hospitalized with severe sepsis, disparities between our investigation and the Rivers' EGDT study, in terms of ScvO2, CVP, and lactate concentration, suggest that threshold levels of ScvO2 and CVP be re-evaluated as resuscitation goals.

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      목차 (Table of Contents)

      • 본문 5
      • 서론 5
      • 재료 및 방법 7
      • 결과 9
      • 고찰 11
      • 본문 5
      • 서론 5
      • 재료 및 방법 7
      • 결과 9
      • 고찰 11
      • 참고문헌 24
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