IgE - 수용체 매개성 호염기구히스타민유리능과 염색체 11q13 유전형 사이의 연관성 = Linkage between gene marker of chromosome 11q13 and IgE - receptor mediated basophil histamine release

다국어 초록 (Multilingual Abstract)

N/A

다국어 초록 (Multilingual Abstract)

Objective : To evaluate that genetic factor(s) in chromosome 11q13 may control the expression of basophil histamine release (BaHR) after anti-IgE stimuli, linkage analysis between this phenotype and gene marker of chromosome 11q13 was performed. Material and methods : BaHR after anti-IgE stimuli and genotyping chromosome 11q13 using microsatellite marker (D11S97) was performed in 56 probands with asthma and 59 their sibs. The linkage between the phenotype and the genotype was evaluated by affected and quantitative trait locus (QTL) sib-pair analysis. Results : Maximal BaHR after anti-IgE were 43.3±3.5% in probands and 29.5±2.6% in sibs, respectively. Of 20 sib-pairs with the maximal BaHR more than 33%, 11 (55%) shared two D11S97 alleles, 9 (45%) shared one allele, neither sib-pair shared identical allele. The sharing rate of D11S97 alleles was 75.5%, which indicates linkage of the phenotype and the genotype (p= 0.026). Difference of the maximal BaHR between probands and their sibs was smaller in sib-pairs with two identical alleles than in those with one identical allele and with no identical allele (14.1±2.5% vs. 25.8±3.1% vs. 40.9±4.9%). Conclusion : Expression of basophil histamine release after anti-IgE stimuli was linked to gene marker of chromosome 11q13.