슈퍼자미벼 미강 추출물 보충 섭취에 의한 항산화 대사 및 혈중 지질 개선 효과 = Effects of Improving Plasma Lipid Profiles and Antioxidant Metabolism of Superjami Extract Supplementation

다국어 초록 (Multilingual Abstract)

This study was to confirm the effect of supplementation of superjami bran extract on lipid and antioxidant metabolism. Twenty-five subjects were recruited, and divided into Superjami group (n=12), and Placebo group (n=13) random assignment. Among the groups, the Superjami group took a Superjami bran extract (2 g/2 capsule/day), and the Placebo group took dextrin (2 g/2 capsule/day), for 12 weeks. As a result of the experiment, concentrations of TG, TC, and HDL-C in the blood, were significantly lower than those in the control group, and HDL-C was significantly higher. AI and HTR also showed positive values. Leptin did not differ significantly, but as a result of adipectin, the Superjami group displayed a higher value, compared to the Placebo group, and LAR also had significantly lower value. Antioxidant results showed that GPx, CAT, and RGLU, were significantly higher before as well as after intakes of the Superjami group, and significantly higher levels of the Superjami group, compared to the Placebo group. AOPP showed significantly lower values for the Superjami group, compared to the Placebo group. So, based on this study, ingestion of Superjami bran extract is effective in improving blood lipid concentrations as well as inflammatory substances, and has positive effects relative to increasing antioxidant activity.

참고문헌 (Reference)

1 전신영, "한국 성인의 식품안정성에 따른 플라보노이드 섭취 실태: 2007~2012년 국민건강영양조사 자료를 이용하여" 한국영양학회 48 (48): 507-518, 2015

2 이경혜, "초기진단 고지혈증 환자의 식습관 조사와 양파가루 섭취가 혈중지질에 미치는 영향 연구" 한국식품영양과학회 37 (37): 561-570, 2008

3 박태식, "율무, 보리, 미강 유기용매 추출물의 항산화능과 포도당 및 지방산 대사에 미치는 영향" 한국식품영양학회 22 (22): 456-462, 2009

4 김은옥, "유색미의 화학적성분 및 항산화활성" 한국식품저장유통학회 15 (15): 118-124, 2008

5 김동주, "유색미 미강발효물의 면역활성 효과" 한국식품영양학회 24 (24): 273-281, 2011

6 박종현, "유색미 도입 유전자원의 생육 및 품질특성 변이 다변량 분석" 한국작물학회 63 (63): 175-185, 2018

7 김성아, "우리나라 성인의 비타민 A 섭취현황 : 2007~2012년 국민건강영양조사 자료를 이용하여" 한국영양학회 49 (49): 258-268, 2016

8 김기쁨, "슈퍼자미의 이화학적 특성 및 항산화 활성" 한국식품조리과학회 28 (28): 789-796, 2012

9 김동주, "슈퍼자미(SuperC3GHi) 미강 발효물의 생리활성" 한국작물학회 56 (56): 420-426, 2011

10 정명근, "복분자 안토시아닌 분획의 항산화, 항암 및 면역증진 효과" 한국약용작물학회 20 (20): 259-269, 2012

11 홍하철, "벼 중생 거대 배아미 발아현미용 신품종 ‘큰눈’" 한국육종학회 44 (44): 160-164, 2012

12 박정숙, "미강에탄올추출물의 RAW264.7 세포에서 항염증효과" 대한약학회 55 (55): 456-461, 2011

13 함태호, "만생 C3G색소 고함유 벼 품종 ‘늦은슈퍼자미’" 한국육종학회 49 (49): 47-51, 2017

14 김용운, "렙틴 저항성" 대한내분비학회 22 (22): 311-316, 2007

15 강지순, "대사증후군 대상자의 건강행위 이행에 영향을 미치는 요인" 한국성인간호학회 24 (24): 191-199, 2012

16 박동수, "기능성 흑찰거대배아미 조생종 벼 품종 ‘눈큰흑찰’" 한국육종학회 47 (47): 68-74, 2015

17 김정순, "국내육성 향미 유전자원과 도입 향미 유전자원의 농업적 형질 평가" 한국작물학회 53 (53): 261-272, 2008

18 조준현, "국내 육성된 향미 품종의이앙시기별 이화학적 특성 및 향기성분 비교 분석" 한국환경농학회 36 (36): 175-183, 2017

19 Akcakaya H, "β-Carotene treatment alters the cellular death process in oxidative stress-induced K562 cells" 41 : 309-319, 2017

20 Noda M, "Transcriptional regulation of osteopontin production in rat osteoblast-like cells by parathyroid hormone" 108 : 713-718, 1989

21 Oda N, "The ratio of leptin to adiponectin can be used as an index of insulin resistance" 57 : 268-273, 2008

22 Van De Wier B, "The potential of flavonoids in the treatment of non-alcoholic fatty liver disease" 57 : 834-855, 2017

23 Jacob RA, "The integrated antioxidant system" 15 : 755-766, 1995

24 Block G, "The data support a role for antioxidants in reducing cancer risk" 50 : 207-213, 1992

25 Nizamutdinova IT, "The anti-diabetic effect of anthocyanins in streptozotocin-induced diabetic rats through glucose transporter 4 regulation and prevention of insulin resistance and pancreatic apoptosis" 53 : 1419-1429, 2009

26 Chen J, "Serum antioxidant vitamins and blood pressure in the United States population" 40 : 810-816, 2002

27 Cicero AFG, "Rice bran and its main components : potential role in the management of coronary risk factors" 3 : 29-46, 2005

28 Hamann A, "Regulation of energy balance by leptin" 104 : 293-300, 1996

29 Choi SP, "Protective effects of black rice bran against chemicallyinduced inflammation of mouse skin" 58 : 10007-11015, 2010

30 Slavin JL, "Plausible mechanisms for the protectiveness of whole grains" 70 : 459S-463S, 1999

31 Hotta K, "Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients" 20 : 1595-1599, 2000

32 Chung SI, "Physicochemical properties of giant embryo rice Seonong 17 and Keunnunjami" 81 : 972-978, 2017

33 Bast A, "Oxidants and antioxidants:state of the art" 91 : S2-S13, 1991

34 Koh HJ, "Nutritional and agronomic characteristics of super-giant embryo mutant in rice" 38 : 537-544, 1993

35 Liu H, "Monitoring oxidative stress in acute-onchronic liver failure by advanced oxidation protein products" 42 : 171-180, 2012

36 Hiramatsu K, "Molecular cloning of the closed circular provirus of human T cell leukaemia virus type I : A new open reading frame in the Gag-Pol region" 68 : 213-218, 1987

37 Bonomini F, "Metabolic syndrome, aging and involvement of oxidative stress" 6 : 109-120, 2015

38 Ishikawa S, "Metabolic syndrome and C-reactive protein in the general population : JMS Cohort Study" 71 : 26-31, 2007

39 Tiku ML, "Malondialdehyde oxidation of cartilage collagen by chondrocytes" 11 : 159-166, 2003

40 Wager JF, "Luminescent impurity doping trends in alternating-current thin-film electroluminescent phosphors" 97 : 68-81, 2002

41 Godala MM, "Lower plasma levels of antioxidant vitamins in patients with metabolic syndrome : A case control study" 25 : 689-700, 2016

42 송수진, "Low consumption of fruits and dairy foods is associated with metabolic syndrome in Korean adults from outpatient clinics in and near Seoul" 한국영양학회 9 (9): 554-562, 2015

43 Caro JF, "Leptin : The tale of an obesity gene" 45 : 1455-1462, 1996

44 Rana P, "In vivo antioxidant potential of rice bran oil(RBO)in albino rats" 48 : 428-436, 2004

45 Hirashima O, "Improvement of endothelial function and insulin sensitivity with vitamin C in patients with coronary spastic angina : possible role of reactive oxygen species" 35 : 1860-1866, 2000

46 강미영, "Hypolipidemic, Hypoglycemic, and Antioxidative Effects of a New Pigmented Rice Cultivar “Superjami” in High Fat-fed Mice" 한국응용생명화학회 57 (57): 685-691, 2014

47 Gu BS, "Gynecology endocrinology" 481-489, 1996

48 Chung SI, "Germinated pigmented rice (Oryza sativa L. cv. Superhongmi) improves glucose and bone metabolisms in ovariectomized rats" 8 : E658-, 2016

49 김정순, "Gas chromatography를 이용한 향미 유전자원의 2-acetyl-1-pyrroline 정량분석" 한국식품과학회 40 (40): 516-521, 2008

50 Machlin LJ, "Free radical tissue damage : protective role of antioxidant nutrients" 1 : 441-445, 1987

51 Friedewald WT, "Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge" 18 : 499-502, 1972

52 Jun SY, "Estimation of dietary flavonoid intake and major food sources of Korean adults" 115 : 480-489, 2016

53 Codoner-Franch P, "Elevated advanced oxidation protein products(AOPPs)indicate metabolic risk in severely obese children" 22 : 237-243, 2012

54 Zawistowski J, "Effects of a black rice extract (Oryza sativa L. indica) on cholesterol levels and plasma lipid parameters in Wistar Kyoto rats" 1 : 50-56, 2009

55 Choi HJ, "Effect of lipid profile and inflammatory marker on serum γ-GT in pre-and post-menopausal women" 13 : 14-20, 2007

56 Kang-Bo Shim, "Effect of Sowing Dates on Flowering and Maturity of Sesame" 한국작물학회 51 (51): 113-117, 2006

57 Kim YH, "Differential scanning calorimetry of skin collagen" 27 : 571-575, 1995

58 Campos H, "Differences in apolipoproteins and lowdensity lipoprotein subfractions in postmenopausal women on and off estrogen therapy : Results from the framingham offspring study" 39 : 1033-1038, 1990

59 Esmaillzadeh A, "Dietary patterns, insulin resistance, and prevalence of the metabolic syndrome in women" 85 : 910-918, 2007

60 Grundy SM, "Diagnosis and management of the metabolic syndrome : An American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement" 112 : 2735-2752, 2005

61 김화영, "Cyanidine-3-glucoside (C3G) 색소의 함유량이 증대된 쌀 신품종(C3GHi)의 항산화 및 항당뇨 활성" 한국작물학회 55 (55): 38-46, 2010

62 함태호, "Correlation Analysis between Grain Color and Cyanidin-3-glucoside Content of Rice Grain in Segregate Population" 한국육종학회 3 (3): 160-166, 2015

63 Zhuo Q, "Comparison of adiponectin, leptin and leptin to adiponectin ratio as diagnostic marker for metabolic syndrome in older adults of Chinese major cities" 84 : 27-33, 2009

64 Deisseroth A, "Catalase : Physical and chemical properties, mechanism of catalysis, and physiological role" 50 : 319-375, 1970

65 Ross RK, "Cardiovascular benefits of estrogen replacement therapy" 160 : 1301-1306, 1989

66 Jang HH, "Black rice (Oryza sativa L.)extract attenuates hepatic steatosis in C57BL/6 J mice fed a high-fat diet via fatty acid oxidation" 9 : 27-, 2012

67 Jang WS, "Black rice (Oryza sativa L.) extracts induce osteoblast differentiation and protect against bone loss in ovariectomized rats" 6 : 265-275, 2015

68 Som S, "Ascorbic acid metabolism in diabetes mellitus" 30 : 572-577, 1981

69 Kim HJ, "Antioxidative activities by water-soluble extracts of Morus alba and Cudrania tricuspidata" 43 : 148-152, 2000

70 Diaz MN, "Antioxidants and atherosclerotic heart disease" 337 : 408-416, 1997

71 Woo KM, "Antioxidant effects of tocotrienol in rice bran" 50 : 4-7, 2005

72 Choi Y, "Antioxidant activity of methanolic extracts from some grains consumed in Korea" 103 : 130-138, 2007

73 Wu Q, "Advanced oxidation protein products as a novel marker of oxidative stress in postmenopausal osteoporosis" 21 : 2428-2432, 2015

74 Koleva DI, "Adipose tissue hormones and appetite and body weight regulators in insulin resistance" 55 : 25-32, 2013

75 Ouchi N, "Adiponectin, an adipocyte-derived plasma protein, inhibits endothelial NF-kappaB signaling through a cAMP-dependent pathway" 102 : 1296-1301, 2000

76 Tilg H, "Adipocytokines : Mediators linking adipose tissue, inflammation and immunity" 6 : 772-783, 2006

77 Nemzer BV, "Acute reduction of serum 8-iso-PGF2-alpha and advanced oxidation protein products in vivo by a polyphenol-rich beverage : A pilot clinical study with phytochemical and in vitro antioxidant characterization" 10 : 67-, 2011

78 Hong S, "A fruit and dairy dietary pattern is associated with a reduced risk of metabolic syndrome" 61 : 883-890, 2012