Lymphopenia is a hallmark of multisystem inflammatory syndrome in children (MIS‐C). We aimed to characterize lymphocyte subsets' shifts and their correlations with other severity markers of MIS‐C. In this prospective cross‐sectional study, we pe...
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https://www.riss.kr/link?id=O111701775
2021년
-
0905-6157
1399-3038
SCI;SCIE;SCOPUS
학술저널
1857-1865 [※수록면이 p5 이하이면, Review, Columns, Editor's Note, Abstract 등일 경우가 있습니다.]
0
상세조회0
다운로드다국어 초록 (Multilingual Abstract)
Lymphopenia is a hallmark of multisystem inflammatory syndrome in children (MIS‐C). We aimed to characterize lymphocyte subsets' shifts and their correlations with other severity markers of MIS‐C. In this prospective cross‐sectional study, we pe...
Lymphopenia is a hallmark of multisystem inflammatory syndrome in children (MIS‐C). We aimed to characterize lymphocyte subsets' shifts and their correlations with other severity markers of MIS‐C.
In this prospective cross‐sectional study, we performed peripheral lymphocyte phenotyping in 32 patients with MIS‐C. We analyzed lymphocyte subsets at three time points of the disease: the acute (A), convalescent (B), and recovery (C) phases. Based on age‐normalized lymphocyte counts, we distinguished two groups of patients: “the mild” (higher lymphocyte counts) and “the severe” (lower lymphocyte counts). In addition, we examined differences between these groups regarding other severity markers.
In phase A, 84% of children had lymphopenia. Decreased absolute counts of CD3, CD4, and CD8 cells were observed in, respectively, 88%, 72%, and 84% of patients. The natural killer cells were decreased in 63% and CD19 in 59% of children. “The severe” group had significantly higher procalcitonin and troponin I levels and lower platelets and albumin. Moreover, “the severe” group had hypotension more frequently (73% vs. 20%, p = .008). In phase B, all lymphocyte counts increased, and 32% of children had lymphocytosis. The increase of CD3, CD4, and CD8 counts correlated with some laboratory severity markers (hemoglobin, procalcitonin, D‐dimer, lactate dehydrogenase, N‐terminal prohormone of brain natriuretic peptide, albumin), but not with steroid use. In phase C, most children had normal lymphocyte counts.
Substantial shifts in lymphocyte counts during MIS‐C apply most to T lymphocytes and correlate with the disease severity markers, particularly hypotension prevalence. A proportion of children with MIS‐C develops transient lymphocytosis during convalescence.
Virological and immunological features of SARS‐COV‐2 infected children with distinct symptomatology