목 적 : 천궁은 중추신경계 신경조직의 손상을 감소시키는 데에 유효한 것으로 보고되었다. 따라서 손상 척수신경에서 천궁에 의한 각각의 신경조직의 반응성을 조사하기 위하여 흰쥐의 손...
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https://www.riss.kr/link?id=A99953061
2008
Korean
519.05
KCI등재
학술저널
19-39(21쪽)
2
0
상세조회0
다운로드국문 초록 (Abstract)
목 적 : 천궁은 중추신경계 신경조직의 손상을 감소시키는 데에 유효한 것으로 보고되었다. 따라서 손상 척수신경에서 천궁에 의한 각각의 신경조직의 반응성을 조사하기 위하여 흰쥐의 손...
목 적 : 천궁은 중추신경계 신경조직의 손상을 감소시키는 데에 유효한 것으로 보고되었다. 따라서 손상 척수신경에서 천궁에 의한 각각의 신경조직의 반응성을 조사하기 위하여 흰쥐의 손상된 척수 신경에 천궁 추출물을 처리하여 관찰하였다. 방 법 : 흰쥐의 척수조직에 타박손상을 가한 후 천궁을 처리하고 손상부위의 GAP-43과 Cdc2 및 Erk1/2 단백질의 수준, 축삭 및 성상세포의 수, 아교상흔의 정도를 각각 확인하여 손상부위 및 피질척수로의 재성장 여부를 관찰하였다. 결 과 : 천궁처리에 의하여 손상부위에서 GAP-43과 Cdc2 및 Erk1/2 단백질의 수준이 증가하였다. 손상척수 부위에서 성상세포의 수는 천궁처리에 의하여 비손상대조군에 비해 증가하였다. CSPG 단백질에 의하여 확인된 아교상흔의 정도는 천궁처리에 의하여 감소하였다. DiI에 의한 정방향 염색에 의하여 피질척수로를 확인하였으며, 측방축삭의 싹돌기는 천궁처리에 의하여 손상부위 상단부 및 하단부에 각각 증가하였다. 고분자미세관을 손상척수부위에 이식하여 미세관내부로 축삭 및 비신경세포의 이주양상을 분석한 결과 천궁처리에 의하여 축삭 및 성상교세포의 이주증가를 확인하였다. 결 론 : 천궁이 손상척수신경부위에서 비신경세포 특히 성상세포의 활성화에 기여함을 알 수 있었다. 이러한 활성화는 손상 피질척수로 축삭의 재성장 반응을 증가시키는 효과가 있는 것으로 판단된다.
다국어 초록 (Multilingual Abstract)
Objectives : It has been reported that CG was effective in decreasing injury to neural tissues. To investigate neural responses in the injured spinal cord, an extract of CG was examined to determine its effect on neural responses in the injured spinal...
Objectives : It has been reported that CG was effective in decreasing injury to neural tissues. To investigate neural responses in the injured spinal cord, an extract of CG was examined to determine its effect on neural responses in the injured spinal cords of rats. Methods : After CG treatment was applied to the spinal cord of rats given a contusion injury, the re-growth responses of injured neural tissues and corticospinal tract axons was observed by measuring the number of GAP-43, Cdc2, and phospho-Erk1/2 proteins, CST axons, GFAP-stained astrocytes, and Glial scarring in the injured spinal cord. Results : Levels of GAP-43, Cdc2, and phospho-Erk1/2 proteins were found to have increased in the injured spinal cord region. The number of GFAP-stained astrocytes also increased within and around the injury cavity. Glial scarring, which was identified by CSPG immunofluorescence staining, was reduced by CG treatment. Anterograde tracing by DiI dye showed that the elongation of the CST axons in the dorso-medial white matter area was almost completely prevented at the injury site. Collateral sprouting was observed in the spinal cord rostrally close to the injury site, and CG treatment further increased axonal arborization in the corresponding region. In vivo migration of CST axons and astrocytes using an implanted polymer tube system showed more of an increase in enhanced migration of axons and astrocytes in CG-treated group compared to the injury control group. Conclusions : These results suggest that CG activated neural responses - including astrocyte migration - and promotes axonal regenerative activity in the injured spinal cord area.
참고문헌 (Reference)
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2 金京善, "川芎의 口腔投與 및 藥鍼施術이 흰쥐 MCAO로 유발된 局所腦虛血에 對한 콜린성 神經保護效果 硏究" 東新大學校 大學院 韓醫學科 31-32, 2004
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4 Fawcett JW, "The glial scar and central nervous system repair" 49 : 373-391, 1999
5 Doree M, "The cyclin-dependent protein kinases and the control of cell division" 8 (8): 1114-1121, 1994
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8 Davis RJ, "Signal transduction by the JNK group of MAP kinases" 103 (103): 239-252, 2000
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1 金善熙, "本草學" 永林社 409-410, 1992
2 金京善, "川芎의 口腔投與 및 藥鍼施術이 흰쥐 MCAO로 유발된 局所腦虛血에 對한 콜린성 神經保護效果 硏究" 東新大學校 大學院 韓醫學科 31-32, 2004
3 Bareyre FM, "Transgenic labeling of the corticospinal tract for monitoring axonal responses to spinal cord injury" 11 (11): 1355-1360, 2005
4 Fawcett JW, "The glial scar and central nervous system repair" 49 : 373-391, 1999
5 Doree M, "The cyclin-dependent protein kinases and the control of cell division" 8 (8): 1114-1121, 1994
6 Konishi Y, "The E2F-Cdc2 cell-cycle pathway specifically mediates activity deprivation-induced apoptosis of postmitotic neurons" 23 (23): 1649-1658, 2003
7 Bradbury EJ, "Spinal cord repair strategies: why do they work?" 7 (7): 644-653, 2006
8 Davis RJ, "Signal transduction by the JNK group of MAP kinases" 103 (103): 239-252, 2000
9 Park J, "Safety and efficacy needs to be tested in appropriate design" 31 (31): 1001-1002, 2003
10 Schwab ME, "Repairing the injured spinal cord" 295 (295): 1029-1031, 2002
11 Silver J, "Regeneration beyond the glial scar" 5 (5): 146-156, 2004
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19 Bareyre FM, "Inflammation, degeneration and regeneration in the injured spinal cord:insights from DNA microarrays" 26 (26): 555-563, 203
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고지방 식이 유도 비만에 대한 대시호탕 추출물의 억제 효과
순기제습방(順氣除濕方)이 고지방식이(高脂肪食餌)로 유발된 비만(肥滿) 백서(白鼠)에 미치는 영향
교통사고로 유발된 경항통 환자의 키네시오 테이핑의 효과에 대한 임상적 연구
조구(S38)-승산(B57)혈의 전침 자극이 동결견 환자의 관절가동범위에 미치는 영향
학술지 이력
연월일 | 이력구분 | 이력상세 | 등재구분 |
---|---|---|---|
2027 | 평가예정 | 재인증평가 신청대상 (재인증) | |
2021-01-01 | 평가 | 등재학술지 유지 (재인증) | |
2018-02-12 | 학술지명변경 | 외국어명 : Journal of oriental rehabilitation medicine -> Journal of Korean Medicine Rehabilitation | |
2018-01-01 | 평가 | 등재학술지 유지 (등재유지) | |
2015-01-01 | 평가 | 등재학술지 유지 (등재유지) | |
2011-01-01 | 평가 | 등재학술지 유지 (등재유지) | |
2008-01-01 | 평가 | 등재학술지 선정 (등재후보2차) | |
2007-01-01 | 평가 | 등재후보 1차 PASS (등재후보1차) | |
2005-01-01 | 평가 | 등재후보학술지 선정 (신규평가) |
학술지 인용정보
기준연도 | WOS-KCI 통합IF(2년) | KCIF(2년) | KCIF(3년) |
---|---|---|---|
2016 | 0.5 | 0.5 | 0.49 |
KCIF(4년) | KCIF(5년) | 중심성지수(3년) | 즉시성지수 |
0.48 | 0.47 | 0.6 | 0.16 |