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정신과 의사와 비정신과 의사의 항우울제 처방에 대한 연구 : 건강보험심사평가원 청구 데이터 중심으로
김민지,김남우,신다운,이상진,박형근,김혜영,양보람,안용민,Kim, Min Ji,Kim, Namwoo,Shin, Daun,Rhee, Sang Jin,Park, C. Hyung Keun,Kim, Hyeyoung,Yang, Boram,Ahn, Yong Min 대한생물정신의학회 2019 생물정신의학 Vol.26 No.2
Antidepressants are widely used to treat depression in Korea, however, only a few studies have focused on the provider of the treatment. The aim of the study is to compare the differences between patients who were prescribed antidepressants by psychiatrists and those who were prescribed antidepressants by non-psychiatrists in South Korea. Patients with a diagnosis of depressive disorder who had been newly prescribed antidepressants in 2012 were selected from the Health Insurance Review and Assessment Service database. They were classified into two groups depending on whether they received the antidepressant prescription from a psychiatrist or non-psychiatrist. Sociodemographic, clinical, and depression related cost has been investigated. Treatment resistant depression, which is defined as a failure of two antidepressant regimens to alleviate symptoms, was also investigated. Prescription adequacy was assessed based on whether a regimen was maintained for at least 4 weeks. Among the 834694 patients with pharmaceutically treated depression (PTD) examined in this study, 326122 (39.1%) were treated by psychiatrists. Patients who were treated by psychiatrists were younger and had more psychiatric comorbidities than those treated by non-psychiatrists. They had longer PTD duration (229.3 days vs. 103.0 days, p < 0.05) and a larger proportion of treatment resistant depression (9.3% of PTD) when compared to those patients treated by non-psychiatrists. The patients treated by psychiatrists had a smaller proportion of inadequate antidepressant use compared to those patients in the non-psychiatrist group (44.5% vs. 65.1%, p < 0.05). The costs related to depression corrected with PTD duration were higher in the non-psychiatrist group (32214 won vs. 56001 won, p < 0.05). Patients who receive antidepressants from psychiatrists are patients with more severe, treatment-resistant depression. Psychiatrists prescribe antidepressants more adequately and cost- effectively than non-psychiatrists.
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붓스트랩에 기초하여 조정한 관리한계를 사용하는 CCC-r 관리도의 성능
김민지,이재헌 한국통계학회 2020 응용통계연구 Vol.33 No.4
CCC-r chart is effective for high-quality processes with a very low fraction nonconforming. The values of process parameters should be estimated from the Phase I sample since they are often not known. However, if the Phase I sample size is not sufficiently large, an estimation error may occur when the parameter is estimated and the practitioner may not achieve the desired in-control performance. Therefore, we adjust the control limits of CCC-r charts using the bootstrap algorithm to improve the in-control performance of charts with smaller sample sizes. The simulation results show that the adjustment with the bootstrap algorithm improves the in-control performance of CCC-r charts by controlling the probability that the in-control average number of observations to signal (ANOS) has a value greater than the desired one. CCC-r 관리도는 불량률이 매우 낮은 고품질 공정을 관리하는 데 효율적이라고 알려져 있다. 대부분의 공정에서 공정 모수의 값은 알려져 있지 않기 때문에 제1국면에서 이를 추정해야 하는데, 표본의 크기가 충분히 크지 않은 경우 추정 오차가 발생하여 원하는 관리상태에서의 성능을 만족하지 못하는 경우가 발생한다. 뿐만 아니라 제1국면에서 추출하는 표본에 따른 산포로 인하여 관리상태일 때의 성능의 산포 또한 커지게 된다. 이러한 문제를 해결하기 위해 이 논문에서는 관리상태일 때 신호까지의 평균관측개수가 사전에 정한 확률로 목표하는 값보다 큰 값을 갖도록, 붓스트랩 알고리즘을 사용하여 CCC-r 관리도의 관리한계를 조정하는 절차를 제안하였다. 이때 고품질 공정에 적용하기 위하여 최대우도추정량 대신 베이즈추정량을 사용하여 불량률을 추정하였다. 다양한 상황에 대해 모의실험을 수행한 결과, 제안된 절차는 CCC-r 관리도의 관리상태 성능을 크게 향상시킴을 알 수 있었다.
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아리랑 5호 위성 영상에서 수계의 의미론적 분할을 위한 딥러닝 모델의 비교 연구
김민지,김승규,이도훈,감진규 한국멀티미디어학회 2022 멀티미디어학회논문지 Vol.25 No.2
The way to measure the extent of damage from floods and droughts is to identify changes in the extent of water systems. In order to effectively grasp this at a glance, satellite images are used. KOMPSAT-5 uses Synthetic Aperture Radar (SAR) to capture images regardless of weather conditions such as clouds and rain. In this paper, various deep learning models are applied to perform semantic segmentation of the water system in this SAR image and the performance is compared. The models used are U-net, V-Net, U2-Net, UNet 3+, PSPNet, Deeplab-V3, Deeplab-V3+ and PAN. In addition, performance comparison was performed when the data was augmented by applying elastic deformation to the existing SAR image dataset. As a result, without data augmentation, U-Net was the best with IoU of 97.25% and pixel accuracy of 98.53%. In case of data augmentation, Deeplab-V3 showed IoU of 95.15% and V-Net showed the best pixel accuracy of 96.86%.
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김민지,윤주영,유석동,이준,전종근,Kim, Min-ji,Yoon, Ju Young,Yoo, Sukdong,Lee, Jun,Cheon, Chong Kun The Korea Society of Inherited Metabolic Disease 2021 대한유전성대사질환학회지 Vol.21 No.1
Purpose: Pseudohypoparathyroidism (PHP) is caused by genetic and epigenetic alteration in the GNAS locus, and characterized by the resistance to multiple hormones and the Albright's hereditary osteodystrophy (AHO) phenotype. This study investigated the phenotypic characteristics and molecular features of PHP. Methods: Eight patients who diagnosed as PHP were enrolled at Pusan National University Children's hospital and clinical features, biochemical and genetic findings were retrospectively reviewed. Results: Of a total of 8 patients, 5 were diagnosed with PHP1a, and 3 were diagnosed with PHP1b. Patients with PHP1a had three different mutations in the GNAS gene, and patients with PHPIb had imprinting defect in differentially methylated regions (DMRs) of the GNAS locus. Two novel GNAS variants were identified in patients with PHP1a, including c.313-2A>T and c.1094G>A. All patients with PHP1a displayed AHO features; short stature (80%), brachydactyly (80%), a round face (80%), obesity (40%), heterotopic ossification (60%), and intellectual disability (60%), whereas only one patient (33.3%) with PHP1b showed AHO feature such as a round face. When phenotypic features between PHP1a and PHP1b patients were compared, patients with PHP1b showed a tendency of higher current height standard deviation scores (SDS) compared to patients with PHP1a, (-3.2±2.1 vs.-1.1±0.8; P=0.06) Conclusions: This study summarizes the phenotypic and genetic features of the PHP patients. Although we found considerable clinical overlap between PHP1a and PHP1b, further long-term follow-up is needed to evaluate the growth and development of children with PHP, as well as the effects of end-organ resistances to endocrine hormones.
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함유황 다당체 Fucoidan의 인체 대장암세포(HT-29) 사멸과 Apoptosis에 미치는 영향
김민지,정하숙,Kim, Min Ji,Chung, Ha Sook 한국식품영양학회 2022 韓國食品營養學會誌 Vol.35 No.3
The purpose of this study was to investigate the biological activity of fucoidan, a sulfur-containing polysaccharide, on cytotoxicity and apoptosis in the human HT-29 colorectal cancer cell line using cell viability, Flow cytometry, Western blot, and RT-PCR analyses. Fucoidan inhibited the proliferation of HT-29 cells by 39.6% at a concentration of 100 ㎍/mL for 72 h. The inhibition was dose-dependent and accompanied by apoptosis. Flow cytometric analysis showed that fucoidan increased early apoptosis and late apoptosis by 65.84% and 72.09% at concentrations of 25 and 100 ㎍/mL, respectively. Analysis of the mechanism of these events indicated that fucoidan-treated cells exhibited increases in the activation of caspase-3, caspase-8, and PARP in a dose-dependent manner. These results suggest that fucoidan may inhibit the growth of human colorectal cancer cells by various apoptosis-promoting effects, as well as by apoptosis itself.
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