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Seung Ku Lee,Hyoun Geun Kim,Jason J Kang,Wonil Oh,Bermseok Oh,KyuBum Kwack 한국유전체학회 2007 Genomics & informatics Vol.5 No.4
Most common diseases are caused by multiple genetic and environmental factors. Among the genetic factors, single nucleotide polymorphisms (SNPs) are comon DNA sequence variations in individuals and can serve as important genetic markers. Recently, investigations of gene-based and whole genome-based SNPs have been applied to association studies for marker discovery. However, SNPs are so population-specific that the association needs to be verified. Fifty-five genes and 384 SNPs were selected based on association with disease. Genotypes of 337 SNPs in candidate genes were determined using Ilumina Sentrix Array Matrix (SAM) chips by an allele- specific extension method in 364 unrelated Korean individuals. Allelic frequencies of SNPs were compared with those of other populations obtained from the International HapMap database. Minor allele frequencies, linkage disequilibrium blocks, tagSNPs, and haplotypes of functional candidate SNPs in 55 genetic disease-associated genes were provided. Our data may provide useful information for the selection of genetic markers for gene- based genetic disease-association studies of the Korean population.
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Acoustic Emission Source Analysis of Vacuum Plasma Sprayed CoNiCrAlY Coatings
Ku-Hyun Lee,이득용,Bae-Yeon Kim,Chae-Hong Jeon,Jin-Hyuo Park,Kyung_Hwan Ye,Seung-Tae Kim,Yo-Seung Song 한국물리학회 2006 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.48 No.6
CoNiCrAlY coatings on Inconel 718 substrate having three different thicknesses (50, 100, and 150 μm) was prepared by vacuum plasma spray process. Thermal barrier coatings (TBCs), composed of 150 μm CoNiCrAlY bond layer by vacuum plasma spray process and 250 μm yttria-stabilized zirconia top coating layer by air plasma spray process, are cyclic-fatigued thermally for 500, 1000, and 2000 cycles at 1050 C. Both specimens were evaluated in 4-point tensile bending conditions by using an advanced acoustic emission (AE) system. The AE count, event, amplitude and energy combined with SEM observation were found to be useful for determining the failure mode and the damage progression. It was found that the 50 μm CoNiCrAlY coating was vulnerable to spallation, however, the tangential cracking was dominant in thicker CoNiCrAlY bond coatings. A reduction in AE event, amplitude and energy was observed for the TBCs fatigued for 2000 cycles, implying adherence between the coatings and the substrate was significantly lowered due to the formation of microcracking, spallation and plastic deformation caused by thermal fatigue.
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A distributed relay selection algorithm for two-hop wireless body area networks
Seung-Ku Kim,Yang-Ick Joo 한국마린엔지니어링학회 2017 한국마린엔지니어링학회지 Vol.41 No.2
This paper investigates two-hop extension communication in wireless body area networks. Many previous studies have demonstrated that two-hop extended topology outperforms single-hop topology. Although many researchers have proposed using two-hop extension communication to improve link reliability, no one has considered using a relay selection algorithm or provided a suitable solution for wireless body area networks. The design goal of the proposed algorithm is selecting a proper relay node to retransmit failed packets distributively. The proposed algorithm configures the carrier sensing period to choose one relay node promptly without requiring additional interaction. We analyze the link conditions corresponding to various body postures and investigate which factors are proper to determine the carrier sensing period. The empirical results show that the proposed algorithm reduces the expected number of transmissions required to deliver a packet successfully.
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Self-reported Sleep Impairment in Functional Dyspepsia and Irritable Bowel Syndrome
Seung Young Kim,Rok Seon Choung,Seung Ku Lee,최정완,Sung Woo Jung,Jong Jin Hyun,Ja Seol Koo,Sang Woo Lee,Chol Shin 대한소화기 기능성질환∙운동학회 2018 Journal of Neurogastroenterology and Motility (JNM Vol.24 No.2
Background/Aims Sleep impairment is a common complaint among patients with irritable bowel syndrome (IBS) and functional dyspepsia (FD). This study aimed to evaluate the prevalence of sleep impairment in FD or IBS patients, and to determine whether IBS-FD overlap induced more sleep disturbance than FD or IBS alone. Methods A population-based cohort in South Korea including 2251 subjects was asked about gastrointestinal symptoms including IBS and dyspepsia-related symptoms. In addition, sleep disturbance was measured using the Pittsburgh Sleep Quality Index and Epworth Sleepiness Scale questionnaires. One-way ANOVA and logistic regression were used to assess differences among the 4 groups (healthy subjects, IBS alone, FD alone, and IBS-FD overlap). Results Of 2251 subjects who were surveyed by questionnaire, 2031 responded (92.5% response rate) and were analyzed. The prevalence of IBS, FD, and IBS-FD overlap was 8.0% (95% confidence interval [CI], 6.8–9.2%), 4.8% (95% CI, 3.9–5.8%), and 1.8% (95% CI, 1.2–2.4%), respectively. FD alone, but not IBS alone, was significantly associated with a poorer sleep quality index (OR, 2.68; 95% CI, 1.43–5.01) and more daytime sleepiness (OR, 2.21; 95% CI, 1.14–4.30), compared to healthy subjects. IBS-FD overlap had the greatest likelihood of a poorer sleep quality index (OR, 3.88; 95% CI, 1.83–8.19), daytime sleepiness (OR, 2.47; 95% CI, 1.01–5.67), and insomnia (OR, 2.84; 95% CI, 1.39–5.82), compared to healthy subjects. Conclusion A correlation between functional gastrointestinal disorders and sleep disturbance was demonstrated, which was significantly pronounced in the context of IBS-FD overlap.
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