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- 저자 : Minjoo Kim (검색결과 239 건)
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( Minjoo Kim ),( Eun-mi Kim ),( Phil-sun Oh ),( Seok Tae Lim ),( Myung-hee Sohn ),( Eun-kee Song ),( Keon Uk Park ),( Jin Young Kim ),( Kyoung Sook Won ),( Hwan-jeong Jeong ) 대한통증학회 2021 The Korean Journal of Pain Vol.34 No.4
Background: Pharmacological and non-pharmacological therapies have been used to treat patients with chemotherapy-induced peripheral neuropathy (CIPN). However, the effect of therapies in cancer patients has yet to be investigated comprehensively. We hypothesized that cyclic thermal therapy would improve blood flow and microcirculation and improve the symptoms driven by CIPN. Methods: The criteria of assessment were blood volume in region of interest (ROI) in the images, and European Organization for Research and Treatment of Cancer- Quality of Life Questionnaire-Chemotherapy-Induced Peripheral Neuropathy 20 questionnaire scores. The blood volume was quantified by using red blood cell (RBC) scintigraphy. All patients were treated 10 times during 10 days. The thermal stimulations, between 15° and 41°, were repeatedly delivered to the patient’s hands. Results: The total score of the questionnaires, the score of questions related to the upper limbs, the score of questions closely related to the upper limbs, and the score excluding the upper limbs questions was decreased. The blood volume was decreased, and the variance of blood volume was decreased. During cooling stimulation, the blood volume was decreased, and its variance was decreased. During warming stimulation, the blood volume was decreased, and its variance was decreased. Conclusions: We suggest that cyclic thermal therapy is useful to alleviate CIPN symptoms by blood circulation improvement. RBC scintigraphy can provide the quantitative information on blood volume under certain conditions such as stress, as well as rest, in peripheral tissue.
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아동학대 행위 부모의 부모교육 참여 경험과 변화과정 - 근거이론적 접근
김민주(Minjoo Kim), 김정은(Jung-Eun Kim) 한국아동가족복지학회 2025 한국가족복지학 Vol.30 No.4
Objective: This study aims to explore the experiences and change processes of abusive parents participating in a parent education program. Methods: In-depth interviews were conducted with six mothers who completed a parent education program designed for perpetrators of child abuse. The collected transcripts were analyzed using grounded theory procedures proposed by Strauss and Corbin (1998). Results: The analysis yielded 28 concepts, which were categorized into 14 subcategories and 6 main categories. The central phenomenon was identified as “crisis and confusion caused by the abuse incident.” Applying the paradigm model, the process of change experienced by abusive parents through participation in the program was revealed in four stages: resistance and denial → acceptance and reflection → practice and change → growth and reestablishment. Conclusions: This study holds significant value as it examines, through grounded theory, the lived experiences of parents who have committed child abuse-a population rarely included in research. By capturing the full process from the occurrence of abuse and offi-cial reporting to the experience of parent education, the study provides empirical insight into understanding the dynamics of abusive behavior and the potential for parental transformation.
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Choi, Ji Hae,Oh, Doori,Kim, In Sun,Kim, Hyeon-Soo,Kim, Minjoo,Kim, Eun-Mi,Lim, Seok Tae,Sohn, Myung-Hee,Kim, Dong Hyun,Jeong, Hwan-Jeong Hindawi 2018 Contrast media and molecular imaging Vol.2018 No.-
<P>Novel probe development for positron emission tomography (PET) is leading to expanding the scope of molecular imaging. To begin responding to challenges, several biomaterials such as natural products and small molecules, peptides, engineered proteins including affibodies, and antibodies have been used in the development of targeted molecular imaging probes. To prepare radiotracers, a few bioactive materials are unique challenges to radiolabelling because of their complex structure, poor stability, poor solubility in aqueous or chemical organic solutions, and sensitivity to temperature and nonphysiological pH. To overcome these challenges, we developed a new radiolabelling strategy based on photoactivated 1,3-dipolar cycloaddition between alkene dipolarophile and tetrazole moiety containing compounds. Herein, we describe a light-triggered radiochemical synthesis via photoactivated click reaction to prepare <SUP>18</SUP>F-radiolabelled PET tracers using small molecular and RGD peptide.</P>
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Kim, Minkyung,Kim, Minjoo,Yoo, Hye Jin,Lee, Seung Yeon,Lee, Sang-Hyun,Lee, Jong Ho Japan Atherosclerosis Society 2018 Journal of atherosclerosis and thrombosis Vol.25 No.2
<P><B><I>Aim</I>:</B> Pulse wave velocity (PWV) is thought to have different relationships with metabolic syndrome (MS) components, inflammatory markers, and oxidative stress, according to age. However, age-specific determinants of PWV have not yet been studied. We investigated age-dependent relationships among PWV and MS components, inflammatory markers, and oxidative stress.</P><P><B><I>Methods</I>:</B> A total of 4,318 subjects were divided into 4 groups: 19–34 y (<I>n</I> = 687), 35–44 y (<I>n</I> = 1,413), 45–54 y (<I>n</I> = 1,384), and 55–79 y (<I>n</I> = 834). MS components, brachial-ankle PWV (baPWV), high-sensitivity C-reactive protein (hs-CRP), and oxidative stress markers were measured.</P><P><B><I>Results</I>:</B> There were age-related increases in MS, body mass index (BMI), waist circumference, systolic blood pressure (SBP), diastolic BP (DBP), triglycerides, glucose, hs-CRP, oxidized low-density lipoprotein (LDL), 8-epi-prostaglandin F<SUB>2<I>α</I></SUB> (8-epi-PGF<SUB>2<I>α</I></SUB>), and baPWV. BaPWV was significantly associated with sex and elevated BP in the 19–34 y group; with age, sex, BMI, elevated BP and triglycerides in the 35–44 y group; with age, sex, elevated BP, fasting glucose, hs-CRP and oxidized LDL in the 45–54 y group; and with age, BMI, elevated BP, fasting glucose and oxidized LDL in the 55–79 y group.</P><P><B><I>Conclusions</I>:</B> Our results show that age-related increases in baPWV are associated with age-related changes in MS components, inflammatory markers, and oxidative stress. However, each of these factors has an age-specific, different impact on arterial stiffness. In particular, oxidative stress may be independently associated with arterial stiffness in individuals older than 45 y.</P>
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Kim, Minkyung,Kim, Minjoo,Kang, Miso,Yoo, Hye Jin,Kim, Min Sun,Ahn, Young-Tae,Sim, Jae-Hun,Jee, Sun Ha,Lee, Jong Ho The Royal Society of Chemistry 2017 Food & Function Vol.8 No.1
<P>Our previous study showed that supplementation with a combination of<I>Lactobacillus curvatus</I>(<I>L. curvatus</I>) HY7601 and<I>Lactobacillus plantarum</I>(<I>L. plantarum</I>) KY1032 reduced the body weight, body fat percentage, body fat mass and L1 subcutaneous fat area in overweight subjects. We aimed to evaluate whether the changes in adiposity after supplementation with<I>Lactobacillus</I>strains were associated with metabolic intermediates. A randomized, double-blind, placebo-controlled study was conducted on 66 non-diabetic and overweight individuals. Over a 12-week period, the probiotic group consumed 2 g of probiotic powder, whereas the placebo group consumed the same product without the probiotics. To investigate metabolic alterations, we performed plasma metabolomics using ultra-performance liquid chromatography and mass spectrometry (UPLC-LTQ/Orbitrap MS). Probiotic supplementation significantly increased the levels of octenoylcarnitine (C8:1), tetradecenoylcarnitine (C14:1), decanoylcarnitine (C10) and dodecenoylcarnitine (C12:1) compared with the levels from placebo supplementation. In the probiotic group, the changes in the body weight, body fat percentage, body fat mass and L1 subcutaneous fat area were negatively associated with changes in the levels of C8:1, C14:1, C10 and C12:1 acylcarnitines. In overweight individuals, probiotic-induced weight loss and adiposity reduction from the probiotic supplementation were associated with an increase in medium-chain acylcarnitines.</P>
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