Octogenarian Brain Tumor Registry: Single-Institution Surgical Outcomes and Mortality Study

( Katharine R. Phillips ),( Aristotelis Filippidis ),( Charles E. Mackel ),( Alejandro Enriquez-marulanda ),( Rafael A. Vega ) 대한뇌종양학회·대한신경종양학회·대한소아뇌종양학회 2023 Brain Tumor Research and Treatment Vol.11 No.2

Background Surgical intervention for brain tumor patients aged 80 to 89 years is controversial, as the comorbidities and physiology associated with aging are often thought to increase surgical risks. Surgical outcomes, however, are not well characterized for octogenarians. This review therefore assessed the outcomes and mortality risk associated with tumor removal in octogenarians at our academic institution. Methods Retrospective review of patients aged 80 to 89 who underwent craniotomy for tumor resection (CTR) at our institution between 2004-2021 and who were diagnosed with meningioma, glioblastoma, or metastatic disease. Primary outcome was 30-day mortality. Results Sixty-one CTRs were included in analysis. Median age was 83 (interquartile range 81-85) years, and the most common preoperative comorbidity was hypertension (n=44). Most patients (n=35) had a preoperative modified Rankin Scale (mRS) score between 0-2. Seventeen (27.9%) patients experienced postoperative complications (i.e., urinary tract infection, deep venous thrombosis, etc.), and 26.2% (n=16) experienced new-onset neurologic deficits postoperatively (i.e., aphasia, motor deficits, etc.). Upon discharge, most patients (n=43) had an mRS score of 3-4. Within 30 days of surgery, 14.8% (n=9) of patients were readmitted to the hospital and 8.2% (n=5) of patients died: 2 with meningioma, 1 with glioblastoma, and 2 with metastatic disease. The most common cause of death was intracranial hemorrhage (n=3). Three-month mortality was 23.0% (n=14). Mean survival after surgery was 33 months for meningioma patients, 6.9 months for glioblastoma patients, and 15 months for patients with metastatic lesions. Conclusion Our review found a 30-day mortality rate of 8.2% across all tumor types, and mean survival was similar to that previously reported for patients across all age groups. Surgical intervention for octogenarian tumor patients is therefore feasible, safe, and likely worthwhile for extending and improving lives.

Teaching Economics through Content Based Instruction

Katharine Y. Cho 한국로고스경영학회 2013 로고스경영연구 Vol.11 No.3

Association of bovine cellular immunity with endotoxin level in dust from Korean beef cattle housing environments

Katharine Roque,GyeongDong Lim,EunSeob Song,Ravi Gautam,JaeHee Lee,YeonGyeong Kim,AhRang Cho,SoJung Shin,ChangYul Kim,HyoungAh Kim,Yong Heo Institute of Natural Science 2016 Quantitative Bio-Science Vol.35 No.2

Hazardous biochemical agents in indoor animal husbandry environments promote the occurrence of various illnesses among husbandry workers and industrial animals. The relationship between endotoxin levels in dust collected from Korean beef cattle farms and markers of bovine cellular immunity was investigated. Peripheral blood was obtained from 25 cattle from five cattle farms in Korea. Endotoxin levels present in total or respirable dust were determined by the Limulus Amebocyte Lysate Kinetic method. Cytokine production was evaluated following the stimulation of peripheral mononuclear cells with concanavalin A for 72 h in a 5% CO₂ incubator. Production of both interleukin (IL)-4 and interferon (IFN)γ was significantly higher in the high endotoxin exposure group (100.9±70.6 EU/m³) compared with the low endotoxin exposure group (17.7±18.6 EU/m³), with a lower IFNγ/IL-4 ratio in animals from the high endotoxin farms, indicating immunity skewed toward a type-2 response. The proportion of γδ T lymphocyte, important bovine immune cells involved in protection against microbial infection, was lower in cattle from the high endotoxin farms than in those from the low endotoxin farms. The numbers of white blood cells, red blood cells, lymphocytes, eosinophils, and basophils were significantly downregulated in cattle from the high endotoxin farms. Overall, these results suggest a probable negative association between dust endotoxin levels and cell-mediated immunity in Korean beef cattle.

A Consideration of Dynamic Corrective Feedback to Develop Writing Accuracy

Katharine Y. Cho 언어과학회 2021 언어과학연구 Vol.- No.97

This study analyzed the efficacy of written corrective feedback on low proficiency students’ writings and in particular dynamic corrective feedback. 64 low proficiency EFL university students were divided into four groups. One group received dynamic feedback(n = 16), the second group received indirect feedback (n =16), the third received direct feedback (n = 16) and the final group received no feedback (n = 16). The study found that only the group that received dynamic written corrective feedback improved in grammatical accuracy from the pre-test to the post-test. Furthermore, none of the groups outperformed the other groups after having received feedback on accuracy for five new writings.

Association of bovine cellular immunity with endotoxin level in dust from Korean beef cattle housing environments

Katharine Roque,임경동,송은섭,Ravi Gautam,이재희,김연경,조아랑,신소정,김창열,김형아,허용 계명대학교 자연과학연구소 2016 Quantitative Bio-Science Vol.35 No.2

Hazardous biochemical agents in indoor animal husbandry environments promote the occurrence of various illnesses among husbandry workers and industrial animals. The relationship between endotoxin levels in dust collected from Korean beef cattle farms and markers of bovine cellular immunity was investigated. Peripheral blood was obtained from 25 cattle from five cattle farms in Korea. Endotoxin levels present in total or respirable dust were determined by the Limulus Amebocyte Lysate Kinetic method. Cytokine production was evaluated following the stimulation of peripheral mononuclear cells with concanavalin A for 72 h in a 5% CO2 incubator. Production of both interleukin (IL)-4 and interferon (IFN)γ was significantly higher in the high endotoxin exposure group (100.9±70.6 EU/m3) compared with the low endotoxin exposure group (17.7±18.6 EU/m3), with a lower IFNγ/IL-4 ratio in animals from the high endotoxin farms, indicating immunity skewed toward a type-2 response. The proportion of γδ T lymphocyte, important bovine immune cells involved in protection against microbial infection, was lower in cattle from the high endotoxin farms than in those from the low endotoxin farms. The numbers of white blood cells, red blood cells, lymphocytes, eosinophils, and basophils were significantly downregulated in cattle from the high endotoxin farms. Overall, these results suggest a probable negative association between dust endotoxin levels and cell-mediated immunity in Korean beef cattle.

Teaching Idioms: “A thorn in the flesh” or “A barrel of laughs?”

Katharine Y. Cho 미래영어영문학회 2018 미래영어영문학회 학술대회 자료집 Vol.2018 No.12

미국의 미학도시 건설 담론

Katharine Kia Tehranian,조일제(번역자) 오늘의 문예비평 2000 오늘의 문예비평 Vol.- No.-

SOUTH KOREA-U.S. RELATIONS

Katharine H. S. Moon 경남대학교 극동문제연구소 2004 ASIAN PERSPECTIVE Vol.28 No.4

This essay focuses on the politics around the U.S. military in Korea as a way to shed light on three challenges confronting the governments and foreign-policy elites in Seoul and Washington. The political consciousness and demands of local governments and residents in South Korea have become more salient in recent years. Nongovernmental organizations (NGOs) have also taken on a more prominent role in forging and articulating national security and foreign policy issues. These interest groups have challenged and eroded the influence of the old political and bureaucratic establishment. As a result, the future of the alliance depends as much on these forces of democratization as on external threats.

Down regulation of cellular immunity in pigs exposed to high endotoxin level in dusts

Katharine Roque,Gyeong Dong Lim,Ravi Gautam,Chanyeol Kim,Hyung Ah Kim,Yong Heo 한국실험동물학회 2015 한국실험동물학회 학술발표대회 논문집 Vol.2015 No.8

Epizootiological characteristics of viable bacteria and fungi in indoor air from porcine, chicken, or bovine husbandry confinement buildings

Katharine Roque,임경동,Ji-Hoon Jo,Kyung-Min Shin,송은섭,Ravi Gautam,김창열,Kyungsuk Lee,신승원,유한상,허용,김형아 대한수의학회 2016 Journal of Veterinary Science Vol.17 No.4

Microorganisms found in bioaerosols from animal confinement buildings not only foster the risk of spreading diseases among livestockbuildings, but also pose health hazards to farm workers and nearby residents. This study identified the various microorganisms present in theair of swine, chicken, and cattle farms with different kinds of ventilation conditions in Korea. Microbial air samples were collected onto Petridishes with bacterial or fungal growth media using a cascade impactor. Endotoxin levels in total dust were determined by the limulus amebocytelysate kinetic QCL method. Prevalent Gram-positive bacteria were Staphylococcus (S.) lentus, S. chromogenes, Bacillus (B.) cereus, B. licheniformis, and Enterococcus faecalis, while the dominant fungi and Gram-negative bacteria were Candida albicans and Sphingomonaspaucimobilis, respectively. Considering no significant relationship between the indoor dust endotoxin levels and the isolation ofGram-negative bacteria from the indoor air, monitoring the indoor airborne endotoxin level was found to be also critical for risk assessmenton health for animals or workers. The present study confirms the importance of microbiological monitoring and control on animal husbandryindoor air to ensure animal and worker welfare.