정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

유도 '되치기 본'의 개선 방안에 관한 연구

김의환,김도준,김규수,김관현,김종달,최종삼,조용철,박순진,윤익선,안병근,정 훈,김미정,한성철 龍仁大學校 武道硏究所 1999 武道硏究所誌 Vol.10 No.1

The purpose of this study was to reform practically a Korean Judo's Doechigi-Bon(Forms of Counterattack, judo's Gaeshi no Kata, Judo's Uradori no Kata, Judo's Gonosen no Kata) that was established in 1955 Korea, according to changing of techniques by Judo's modernization, in order to have Judo's carefulness and systematic diffusion. Reform procedure of Judo's Doechigi-Bon was 1st stage, Questionnaire survey 303 judokas, 2nd stage, Technical seminar by judo experts(12 judo professor) 4 times, 3rd stage, wording report for reform, 4rd stage, Discussion and judgement of Teaching and Judgement commission of Korean judo Association(KJA), 5th stage, Public hearing for reform in KJA, 6th stage, Report and decision of board of directors in KJA, 7th stage, public publication of Judo News(No.53) in KJA. Basic principle of reform of Judo's Doechigi-Bon were as table 1. Table 1. Basic principle of reform of Judo's Doechigi-Bon ------------------------------------------------------------------------------- Items Reformed Key Points of Judo's Doechigi-Bon ------------------------------------------------------------------------------- 1. Structure 1) Grand classification : Classified by 3 parts(1,2,3Gyo) 2)Medium classification : Te waza, Goshi waza, Ashi waza devided per each part(Gyo) 3)Sub-classification : Classified five techniques per each part(Gyo) 2. Contents 1) Selected established techniques as possible 2) Considered rationalty and overlapping of counterattack techniques 3. Decision of Conterattack techniques 1) Refered to results of Basic Questionnaire survey 2) Priority to decisions of Judo expert technical seminar -------------------------------------------------------------------------------- Reformed Korean Judo's Doechigi-Bon(Forms of Counterattack techniques-KJA, 1999) are as follows: 1. Gyo; ① Uki otoshi -> Uchi mata ② Harai goshi -> Harai goshi gaeshi ③ O soto gari -> O soto gake ④ Ko uchi gari -> Sasae tsurikomi ashi ⑤ O uchi gari -> Ko soto gari 2. Gyo; ① Ippon seoi nage -> Okuri eri jime ② Tsuri domi goshi -> Uki waza ③ Okuri ashi harai -> Okuri ashi harai ④ Ko soto gari -> Tai otoshi ⑤ Hiza guruma -> Hiza guruma 3. Gyo; ① Kata guruma -> Sumi gaeshi ② Tai otoshi -> Ko soto gari ③ Hane goshi -> Harai tsurikomi ashi ④ Uchi mata -> Tai otoshi ⑤ Tomoe nage -> O uchi gari

직업적 연폭로가 일부 신경행동학적 검사수행에 미치는 영향

안익수,안현철,김용배,리갑수,김화성,황규윤,최은,장봉기,이성수,안규동,이병국 순천향대학교 산업의학연구소 1999 순천향산업의학 Vol.5 No.1

In order to investigate that blood lead levels of lead exposed workers is associated with decreased performance in neurobehavioral tests in adults, we investigate 78 workers in a battery industry. Three items among neurobehavioral core test battery of World Health Organization, including digit span, Santa ana dexterity, digit symbol were administered to workers occupationally lead exposed workers by operational guide for the WHO neurobehavioral core test battery. Blood lead (PbB) and zinc protoporphyrin in whole blood (ZZP) were selected as an index of lead exposure. Detailed occupational history such as exposed agent, age, work duration, smoking and drinking habits, were recorded as confounding factors. After controlling age, the results of digit span and digit symbol among the neurobehavioral tests were significant contributed by PbB.

QT연장 증후군 환자에서 Head-Up Tilt Test에 의해 유발된 Torsades De Pointes 1례

전익수,차태준,김길수,김동완,김규종,김찬욱,김성만,주승재,이재우 대한순환기학회 2000 Korean Circulation Journal Vol.30 No.8

혼합 식물추출물에 대한 차응애의 감수성 검정

김창승(Chang Seung Kim),김도익(Do Ik kim),국용인(Yong In Kuk),현규환(Kyu Hwan Hyun),김상수(Sang Soo Kim1) 한국차학회 2016 한국차학회지 Vol.22 No.1

The acaricidal activity of the mixed plant extracts of Gleditsia japonica var. koraien, Camellia sinensis, Cinnamomum cassia, and Lantana camara, toward the tea red spider mite, Tetranychus kanzawai Kishida was evaluated in laboratory bioassays. Treatments with mixtures 1 and 3 were effective against the adult females of T. kanzawai and yielded 87.0 and 85.6% adulticidal activity at 7 days after treatment, respectively. Mixture 3 revealed 78.7% adulticidal activity. However, mixtures 4 and 5 had lower adulticidal activity than the other treatments. The adult females of T. kanzawai treated with mixtures 1 and 3 produced only 22.5-22.8% as many eggs as did the control females. The residue of the plant extracts tested had low adulticidal activity (16.3-27.2%). All of the plant extracts tested were ineffective against the eggs of T. kanzawai. Treatments with mixtures 1 and 3 were effective against the nymphs of T. kanzawai and led to emergence rates of 20.7 and 25.3%, respectively. These results suggest that mixtures 1 and 3 might be used for the control of T. kanzawai.

체외순환시 적혈구 용혈현상에 hydrocortisone이 미치는 영향

김익수,이원형 충남대학교 의과대학 지역사회의학연구소 1986 충남의대잡지 Vol.13 No.2

The sequelae of extracorporial circulation during open heart surgery are hemolysis, air embolism, pulmonary failure, etc. Hemolysis which may result in acute tubular damage of kidney if it is severe, occured by mechanical trauma of red blood cell membrane with pump or sucker The present study was undertaken to observe the effect of hydrocortisone for hymolysis during extracorporial circulation. The result are as follows; 1) A significant hemolysis occured 60 minutes after extracorporial circulation compare to control value in both control and hydrocortisone group. 2) A significant hemolysis occured 90 minutes after compare to 30 minutes value in control group. 3) A significant hemolysis occured 120 minutes after compare to 30 minutes value in hydrocortisone group.

잡견 적출기관의 Acetylcholine 작용에 대한 마취제의 영향에 관한 연구

김익수,김태헌 충남대학교 의과대학 지역사회의학연구소 1985 충남의대잡지 Vol.12 No.1

Severe bronchospasm occuring during general anesthesia is rare but potentially lethal anesthetic emergency. Several anesthetics charge with that situation. To assess correlation on airway smooth muscle, the authors studied the effects of three intravenous anesthetics, four muscle relaxants and three local anesthetics that used on acetylcholine 10ug/cc induced tone of mongrel dog tracheal chains. The results are summarized as follow: 1. In the intravenous anesthetics group, thiopental and propanidid induced dose-dependent relaxation on acetylcholine contracture significantly, while ketamine induced variable contraction according to dose administered. 2. In the muscle relaxants group, pancuronium and gallamine induced dose-dependent relaxation on acetylcholine contracture significantly, while succinylcholine and d-tubocurarine induced dose-dependent contracture significantly. 3. the local anesthetics group, lidocaine and procaine showed dose-dependent relaxation on acetylcholine contracture significantly, but tetracaine produced contraction at lower concentration and relaxation at higher concentration.

韓國産 모래무지亞科(Cyprinidae) 魚類의 系統分類學的 硏究

金益秀 全北大學校 生物學硏究所 1984 生物學硏究年報 Vol.5 No.-

The taxonomy of gudgeons of the subfamily Gobioninae in Korea is reviewed and keys to supraspecific taxa (subfamilies and genera) of the sub family Gobioninae are provided, as well as the synonyms and distribution of the species or subspecies. Abbottina springeri, poorly known in Korea is redescribed with the extention of its known morphological characters and geographical distribution. Squalidus sp. occurring rivers of the Yo˘ngdo˘koship, the Hyo˘ngsan, and the Hoeya in the Gyongsangbugdo and in the Gyo˘ngsangnamdo differs from three previously described species from Korea in the numbers and structure of lateral line scales, color patterns on the body sides, and eye diameter etc. The genus name of Gonoproktopterus mylodon should be transferred from Gonoproktopterus to Hemibarbus, because the species is more similar to Hemibarbus longirostris or Belligobio eristrigma than to Gonoproktopterus, an Indian genus of Earbinae. The korean gudgeons of the subfamily Gobioninae are grouped five possible phyletic series, as follow; Hemibarbus, Pseudorasbora, Sarcocheilichthys, Gnathopogon, and Pseudogebio group. The genus Gobiobotia is not placed in the subfamily Gobionibae but in the subfamily Gobiobotinae in relation to 3 pairs of mental barbels and some osteological characters.

韓國産 동자개科 魚類의 分類學的 硏究

金益秀,李金永,朱日永 全北大學校 生物學硏究所 1981 生物學硏究年報 Vol.2 No.-

The taxonomy of the species of the family Bagridae from Korea is reviewed and the keys to the following eight species of Korean bagrid fishes are presented: Pelteobagrus fulvidraco (RICHARDSON), P. nitidus (SAUVAGE and THIERSANT), Pseudobagrus ussuriensis (DIBOWSKY), Ps. sp. UCHIDA, Leiocassis longirostris GU¨NTHER, Coreobagrus brevicorpus MORI, Liobagrus andersoni REGAN, and L. mediadiposalis MORI. Among them P. nitidus, previously known only from Chinese waters, is firstly recorded from 26 specimens collected mainly off the lower course along the Geum River in the present study. Comparison with P. vachelli of which many paper have recorded from Korea, shows that P. nitidus differs from it in number of gill raker(9-11) and in the short length of its maxillary barbels. The 36 bagrid specimens, which were collected in the Han and Geum River in this study was identified as Pseudobagrus ussuriensis of which the species identification was not confirmed formerly in Korea. The critical examinations of the specimens and the previous discriptions refered to Ps. ussuriensis and Ps. emerginatus SOWERBY (Not REGAN) revealed that Ps. emerginatus mostly used in Korea is a synonym of Ps. ussuriensis. Ps. sp. UCHIDA is clearly distinguishable from other twelve relative species of the genus Pseudobagrus on the bases such as the length of maxillary barbel, serrate structure on the anterior part of pectoral spine, and several morphometric characters. Therefore Pseudobagrus sp. is regarded as a valid species. The six atypical specimens of the genus Liobagrus collected in the Geum River are considered to be natural hybrid between L. andersoni and L. mediadiposalis on the basis of the length of jaw and of the number of feeble teeth on the posterior part its pectoral spine. Interspecific relationships were investigated in the species of Korean bagrid fishes on the basis of the features of the morphological characters and the pattern of aqueous soluble muscle protein.

韓國産 납자루亞科 魚類의 分類學的 硏究

金益秀 全北大學校 生物學硏究所 1982 生物學硏究年報 Vol.3 No.-

The taxonomy of the fishes of the subfamily Acheilognathinae from Korea is reviewed and keys to following six species of Rhodeus, seven species or subspecies of Acheilognathus, and two species of Acanthorhodeus are presented : Rhodeus hndae, R.ocellatus, R. sericeus, R.notatus, R.uyekii, R.suigensis, Acheilognathus limbata, A.intermedia intermedia, A.intermedia ssp., A.yamatsutae, A.cyanosigma, A.rhombea, A.tabira, Acanthorhodeus asmussi, and Ac.gracilis. Acheiiognathus intermedia contains two subspecies. A intermedia ssp., from muddy bottom habitats, has shorter barbeles than A. intermedia intermedia. A. cyanostigma, poorly known in Korea, is redescribed on the basis of five specimens and recorded for the first time from the upper courses of the Mangyong River and the Nagdong River. Rhodeus atremius, incorrectly record from Korea, was identified as R. notarus, a species showns to be widely distributed in the south-western parts of Korea. Acheilognathus signifer is a junior synonym of A. limbata. Both Acanthorhodeus assumussi and A. gracilis of Korea are not hybrids as suggested by Holicik(1963). Both are morphologically distinct, and considered to be valid species.